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SRP5176

c-JUN (1-79), GST tagged human

Name: c-JUN (1-79), GST tagged human
Brand: SIGMA

recombinant, expressed in E. coli, ≥50% (SDS-PAGE), buffered aqueous glycerol solution

别名:

AP1

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关于此项目

化学文摘社编号:

913305-50-7

NACRES:

NA.32

UNSPSC Code:

12352200

Assay:

≥50% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

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属性

biological source

human

recombinant

expressed in E. coli

assay

≥50% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~35 kDa

NCBI accession no.

NM_002228

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... JUN(3725)

说明

General description

c-Jun is a proto-oncogene that forms a complex with c-Fos which regulates transcription from promoters containing AP-1 activation elements. c-Jun has specific DNA binding activity and following in vitro translation, c-Jun binds as a homodimer to the AP-1 DNA site. The transactivating function of c-Jun is acutely regulated by a wide variety of cellular signals via modulation of phosphorylation of two serines (63 and 73). Jun N-terminal domain kinases (JNKs), are responsible for mediating S63/73 phosphorylation on c-Jun in response to a variety of cellular stimuli including TNF-a, heat stress and u.v. light.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c