SRP5182
FRS3, GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
FRS2β, FRS2B, MGC17167, SNT2
重组
expressed in baculovirus infected Sf9 cells
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
~87 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... FRS3(10817)
一般描述
FRS3 or fibroblast growth factor receptor substrate 3 is a peripheral plasma membrane protein that is a substrate for the fibroblast growth factor receptor. During FGF or NGF stimulation, FRS3 becomes tyrosine phosphorylated and then serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-MAP kinase signaling cascade. FRS3 is mainly expressed in fibroblast and myoblast cell lines and undergo robust tyrosine phosphorylation in response to several mitogenic ligands. Through interaction with Rho family of small GTPases, FRS3 has been implicated in the reorganization of the actin cytoskeleton and subsequent morphological changes in various cells.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Lin Huang et al.
Biochemical and biophysical research communications, 324(3), 1011-1017 (2004-10-16)
The control of cellular responses with fibroblast growth factors and neurotrophins is mediated through membrane-linked docking proteins, SNT (suc1-binding neurotrophic target)-1/FRS2alpha and SNT-2/FRS2beta. ERK1/2 are members of the mitogen-activated protein kinase family that regulate diverse cellular activities in response to
H Xu et al.
The Journal of biological chemistry, 273(29), 17987-17990 (1998-07-11)
Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras. Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated
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