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Merck
CN

SRP5186

HO2, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

HMOX2

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关于此项目

NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in E. coli

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产品名称

HO2, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~62 kDa

NCBI accession no.

NM_002134

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HMOX2(3163)

General description

HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase. HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia. Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

存储类别

10 - Combustible liquids

wgk

WGK 1

法规信息

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分析证书(COA)

Lot/Batch Number
W259-4

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Sandile E J Williams et al.
Science (New York, N.Y.), 306(5704), 2093-2097 (2004-11-06)
Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the identity of the oxygen sensor remains unknown. We demonstrate that hemoxygenase-2 (HO-2) is
Paul J Kemp
Biochemical and biophysical research communications, 338(1), 648-652 (2005-09-03)
The physiological response of the carotid body is critically dependent upon oxygen-sensing by potassium channels expressed in glomus cells. One such channel is the large conductance, voltage- and calcium-dependent potassium channel, BK(Ca). Although it is well known that a decrease

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