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SRP5194

I?Bα, GST tagged human

Name: I?Bα, GST tagged human
Brand: SIGMA

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

MAD-3, NFKBI, NFKBIA

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352202

Form:

buffered aqueous glycerol solution

Assay:

≥70% (SDS-PAGE)

Recombinant:

expressed in E. coli

Mol wt:

~61 kDa

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属性

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~61 kDa

NCBI accession no.

NM_020529

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NFKBIA(4792)

说明

General description

IκBα is an inhibitor of the NFκB complex and inactivates the NFκB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IκB protein by IκB kinases (IKKs) marks it for destruction via the ubiquitination pathway, thereby allowing the activation of the NFκB complex. Synthetic glucocorticoid such as dexamethasone display anti-inflammatory effects by inducing the increased synthesis of the IκB protein thereby inhibiting the activity of the NFκB complex. Overexpression of the IκBα gene in fibroblasts leads to inhibition of production of IL-6, TNF receptor, MMP-1, MMP-3 and MMP-13.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c