SRP5205
MBP, GST标记 人
recombinant, expressed in E. coli, ≥65% (SDS-PAGE), buffered aqueous glycerol solution
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关于此项目
Form:
buffered aqueous glycerol solution
Assay:
≥65% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~36 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥65% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~36 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MBP(4155)
General description
髓鞘碱性蛋白（MBP）是 CNS（中枢神经系统）髓鞘的重要组成部分，是一种自身免疫原。它定位于人类染色体 18q 上。
Biochem/physiol Actions
MBP 或髓鞘碱性蛋白在髓磷脂形成过程中形成跨胞质的二聚体。涉及折叠、聚合和底物特异性的蛋白质区域在各种物种中均是保守的，并且在髓磷脂膜中的蛋白质-脂质相互作用中可能具有特殊作用。MBP 是多种蛋白激酶的有效底物，与 MARCKS 蛋白具有相似性，均具有受其环境调控的扩展构象、N 末端修饰，与脂质相互作用的双重性质以及与肌动蛋白和 Ca2+-钙调蛋白的结合。髓鞘碱性蛋白（MBP）预期在 MS（多发性硬化症）等脱髓鞘疾病中发挥重要作用。
Physical form
以 50 mM Tris-HCl，pH 7.5，150mM NaCl，10 mM 谷胱甘肽，0.1 mM EDTA，0.25 mM DTT，0.1 mM PMSF，25％ 甘油的形式提供。
Preparation Note
开封后，分装少量，-70℃ 储存。避免重复处理和多次冻融循环
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
G Harauz et al.
Molecular and cellular biochemistry, 209(1-2), 155-163 (2000-08-15)
Myelin basic protein (MBP) and myristoylated alanine-rich C-kinase substrate (MARCKS) are similar in terms of having extended conformations regulated by their environment (i.e., solubilised or lipid-associated), N-terminal modifications, a dual nature of interactions with lipids, binding to actin and Ca2+-calmodulin
B E Chapman et al.
Advances in experimental medicine and biology, 100, 207-220 (1978-01-01)
High resolution 13C and 1H NMR spectra of myelin basic protein over a range of pH and concentrations indicate that intramolecular folding of the polypeptide chain occurs in aqueous solution in the region of residues 85 to 116. At pH
Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
Campagnoni AT, et al.
Test, 268(7), 4930-4938 (1993)
Molecular characterization of a patient with central nervous system dysmyelination and cryptic unbalanced translocation between chromosomes 4q and 18q
Gunn S R, et al.
American Journal of Medical Genetics. Part A, 120(1), 127-135 (2003)
Variation within MBP gene predicts disease course in multiple sclerosis
Zhou Y, et al.
Brain and Behavior, 7(4), e00670-e00670 (2017)
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