重组
expressed in E. coli
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
~91 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... GRB7(2886)
一般描述
GRB7 or growth factor receptor-bound protein 7 belongs to a small family of adapter proteins which interact with a number of receptor tyrosine kinases and signaling molecules. GRB7 encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. GRB7 is highly expressed in liver and kidney. GRB7 isoforms are involved in cell invasion and metastatic progression of human esophageal carcinomas. GRB7 plays an important role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK).
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
储存分类代码
10 - Combustible liquids
WGK
WGK 1
法规信息
新产品
S Tanaka et al.
The Journal of clinical investigation, 102(4), 821-827 (1998-08-26)
The cDNAs of a putative growth factor-bound (Grb) 7 signal transduction molecule and Grb7V novel splice variant were isolated from an invasive human esophageal carcinoma. Although both Grb7 isoforms share homology with the Mig-10 cell migration gene, the Grb7V isoform
E Y Skolnik et al.
Cell, 65(1), 83-90 (1991-04-05)
A novel method has been developed to allow cloning of protein targets for receptors with tyrosine kinase activity. By utilizing the carboxy-terminal tail of EGF receptor (EGFR) as a probe to screen lambda gt11 expression libraries, several EGFR-binding proteins have
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