SRP6006
IL-1RA murine
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
别名:
ICIL-1RA, IL-1ra3, IL1 inhibitor, IL1F3, IRAP
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in E. coli
Mol wt:
17.4 kDa
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
mol wt
17.4 kDa
packaging
pkg of 50 μg
technique(s)
activity assay: suitable
impurities
Endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... IL-1RA(16181)
General description
Research area: IMMUNO AND CKS
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.
Application
IL-1RA murine has been used as an antagonist to the interleukin-1 receptor in fibroblasts.
Biochem/physiol Actions
Interleukin-1 receptor antagonist (IL-1Ra) protein mediates the inhibition of interleukin 1-α (IL1A) and interleukin 1-β (IL1B) activities. It is also involved in the modulation of IL-1 related immune and inflammatory responses. A polymorphism in the IL-1Ra gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1Ra is effective in treating bronchopulmonary dysplasia in murine models.This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B) and modulates a variety of interleukin 1 related immune and inflammatory responses.
Physical form
Lyophilized from H?O containing NaHCO?
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile ddH?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Other Notes
The IL1RA is purified by proprietary chromatographic techniques.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable