SRP6119
DHFR from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
别名:
DYR, Dihydrofolate reductase, N/A
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352204
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE)
Form:
liquid
Mol wt:
23.8 kDa (207 aa, 1-187 aa + NT His-Tag)
biological source
mouse
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
23.8 kDa (207 aa, 1-187 aa + NT His-Tag)
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... DHFR(13361)
General description
Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. The gene encoding this protein is localized on mouse chromosome 13.
Biochem/physiol Actions
DHFR catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
Physical form
1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 2 mM DTT and 10% glycerol.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MGSSHHHHHH SSGLVPRGSH MVRPLNCIVA VSQNMGIGKN GDLPWPPLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS IPEKNRPLKD RINIVLSREL KEPPRGAHFL AKSLDDALRL IEQPELASKV DMVWIVGGSS VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLGKYKLL PEYPGVLSEV QEEKGIKYKF EVYEKKD
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes.
Askari BS and Krajinovic M
Current Genomics, 11(8), 578-583 (2010)
M N Lombardo et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(9), 995-1003 (2019-06-16)
Pharmacokinetic/pharmacodynamic properties are strongly correlated with the in vivo efficacy of antibiotics. Propargyl-linked antifolates, a novel class of antibiotics, demonstrate potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria, including multidrug-resistant Staphylococcus aureus Here, we report our efforts to
A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci.
Justice MJ
Genomics, 6(2), 341-351 (1990)
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