SRP6153
Activin A human
recombinant, expressed in human cells, ≥95% (SDS-PAGE)
别名:
FRP, FSH-releasing protein, Inhibin beta A
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关于此项目
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in human cells
Mol wt:
25 kDa (homodimer, non-glycosylated)
SMILES string
O(C2C3(C(C4C(C5CCC(=O)C=C5CC4)CC3)CC2)C)C(=O)CCc1ccccc1
InChI
1S/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10-23(22)24(27)12-13-25(27)30-26(29)14-7-18-5-3-2-4-6-18/h2-6,17,21-25H,7-16H2,1H3
InChI key
UBWXUGDQUBIEIZ-UHFFFAOYSA-N
biological source
human
recombinant
expressed in human cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
25 kDa (homodimer, non-glycosylated)
packaging
pkg of 10 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... INHBA(3624)
General description
Activins are homodimers or heterodimers of the different subunit isoforms, part of the TGF-? super-family. Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, hematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells. BioVision′s Activin A is produced in a serum-free, chemically de?ned media.
Physical form
Lyophilized from a PBS solution.
Preparation Note
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Centrifuge the vial prior to opening.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Yan Li et al.
The Journal of clinical endocrinology and metabolism, 100(11), E1415-E1427 (2015-08-26)
Activin A increases matrix metalloproteinase (MMP) 2 expression and cell invasion in human trophoblasts, but whether the expression of MMP2 is essential for the proinvasive effect of activin A has yet to be determined. Moreover, the identity of the activin
Hannah E J Yong et al.
Pregnancy hypertension, 5(4), 346-353 (2015-11-26)
Activin A, a TGFβ family member, circulates in the maternal blood at increasing concentrations throughout gestation during a healthy pregnancy. The circulating concentration of activin A is further increased in pre-eclampsia (PE), a hypertensive disorder of pregnancy that is marked
Xu Qian et al.
Biomaterials, 35(36), 9581-9590 (2014-09-06)
Well-defined culture conditions are essential for realizing the full potential of human embryonic stem cells (hESCs) in regenerative medicine where large numbers of cells are required. Synthetic polymers such as poly[2-(methacryloyloxy) ethyl dimethyl-(3-sulfopropyl) ammonium hydroxide] (PMEDSAH), offer multiple advantages over
Yasuhide Ohinata et al.
PloS one, 9(9), e107308-e107308 (2014-09-10)
The inner cell mass (ICM) and trophoblast cell lineages duet early embryonic development in mammals. After implantation, the ICM forms the embryo proper as well as some extraembryonic tissues, whereas the trophoectoderm (TE) exclusively forms the fetal portion of the
Melissa L Brown et al.
Islets, 6(5-6), e1017226-e1017226 (2015-04-04)
Emerging evidence suggests that activin with its associated receptors, second messengers, and antagonists would be excellent targets for therapeutic drug development in the treatment of diabetes. We undertook the current study to investigate the ability to extrapolate findings from rodent
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