产品名称
IL18BP human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
20 kDa (187 aa, 31-194 aa + His Tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IL18BP(10068)
General description
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn′s disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Ahmet Bal et al.
The Journal of surgical research, 201(1), 13-21 (2016-02-07)
The aim of this study was to investigate the possible protective effect of interleukin 18-binding protein (IL-18BP) on ischemia-reperfusion (I/R)-induced liver injury in experimental rat models. Liver is one of the most affected organs from I/R process. IL-18 is an
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