SRP6362
IL13RA2 human
recombinant, expressed in E. coli, ≥85% (SDS-PAGE)
别名:
CD213A2, CT19, IL-13R, IL13BP, Interleukin-13 receptor subunit alpha-2 precursor
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
≥85% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
39.5 kDa (340 aa, 27-343 aa + His Tag)
biological source
human
recombinant
expressed in E. coli
assay
≥85% (SDS-PAGE)
form
liquid
mol wt
39.5 kDa (340 aa, 27-343 aa + His Tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IL13RA2(3598)
General description
IL13Rα2 (interleukin 13 receptor subunit alpha 2) is a 42 kDa monomeric high affinity IL13 receptor. This gene is located on human chromosome Xq.
IL13RA2 is closely related to Il13RA1, a subunit of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. Recombinant human IL13RA2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Biochem/physiol Actions
IL-13Rα2 (interleukin 13 receptor subunit α 2) induces the progression, migration and invasion of glioma cells. It has the ability to initiate Scr (selective catalytic reduction), phosphatidylinositol 3 kinase (PI3K), Akt (signaling pathway) and mTOR (mammalian target of rapamycin). IL-13Rα2 chain plays a key role in IL-13 cytotoxin-mediated therapy. It is expressed at high levels in several human tumors such as oral squamous cell carcinoma, breast cancer, clear cell renal cell carcinoma, hepatic cell cancer, ovarian cancer and colorectal cancer.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable