生物来源
human
重组
expressed in HEK 293 cells
标签
6-His tagged (C-terminus)
方案
≥90% (SDS-PAGE)
表单
lyophilized
分子量
calculated mol wt 25.4 kDa
observed mol wt 40 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminus.)
包装
pkg of 10 μg
杂质
<1 EU/μg endotoxin (LAL test)
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... IL2RB(3560)
一般描述
Interleukin-2 receptor (IL-2R)/ cluster of differentiation 122 (CD122) is a heterotrimeric protein, encoded by the gene mapped to human chromosome 22q12.3. The encoded protein is expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α subunit is involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. IL2R β is a member of the type I cytokine receptor family.
应用
Interleukin 2 receptor subunit β (IL2RB)/cluster of differentiation 122 (CD122) human has been used to study the effect of this cytokine on the expression of Klf15 in neurons.
生化/生理作用
Interleukin 2 receptor subunit β (IL2RB) is involved in signal transduction via its ligand interleukin-2. It is also implicated in inflammation. Cluster of differentiation 122 (CD122) is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
外形
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
制备说明
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Cytokine receptor signaling through the Jak?Stat?Socs
pathway in disease.
pathway in disease.
Lynda A O, et al.
Molecular Immunology, 44, 2497-2506 (2007)
Autologous Regulatory T Cells for the Treatment of Type 1 Diabetes.
James A T, et al.
Current Diabetes Reports, 12(5), 623-632 (2012)
Oxalate upregulates expression of IL-2Rβ and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cells.
Koul S, et al.
American Journal of Physiology: Renal Physiology, 306(9), F1039-F1046 (2014)
Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.
Sharon M, et al.
Science, 234(4778), 859-863 (1986)
Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis
Bielekova B, et al.
Proceedings of the National Academy of Sciences of the USA, 103(15), 5941-5946 (2006)
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