SRP6450
脑啡肽/CD10 人
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
别名:
CALLA, DKFZp686O16152, MGC126681, MGC126707, MME, NEP, SFE
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
calculated mol wt 80 kDa, observed mol wt 90-100 kDa (DTT-reduced. Tyr 52 is the predicted N-terminal .)
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
calculated mol wt 80 kDa, observed mol wt 90-100 kDa (DTT-reduced. Tyr 52 is the predicted N-terminal .)
packaging
pkg of 10 μg
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MME(4311)
General description
分化簇10（CD10）也被称为膜金属内肽酶、中性内肽酶（NEP）、中性溶酶和常见急性淋巴细胞白血病抗原（CALLA）。它是一种90-110kDa的II型跨膜糖蛋白，通常由多种组织表达，包括前列腺、肾脏、肠、子宫内膜、肾上腺和肺的上皮细胞。该蛋白质具有胞质氨基末端结构域、跨膜疏水结构域和具有催化活性的细胞外结构域。编码该蛋白的基因位于人类染色体3q25.2上。
Biochem/physiol Actions
分化簇10（CD10）是一种锌依赖性金属蛋白酶，可切割疏水残基氨基侧的肽键，并可使多种生理活性分泌肽失活。它被认为是淀粉样蛋白-β肽（Aβ）的限速降解酶，其在神经组织中的异常错误折叠和聚集与阿尔茨海默病（AD）的发展有关。CD10还被确定为前B表型白血病细胞上的常见急性淋巴细胞白血病抗原（CALLA），因此在诊断人类急性淋巴细胞白血病（ALL）中起着最重要的生物标记作用。
Physical form
从经过0.22μm过滤的含有50 mM tris（pH 8.0）、150 mM NaCl的溶液中冻干得到。通常添加甘露醇或海藻糖作为保护剂。
Preparation Note
打开前离心小瓶。用无菌 PBS (pH 值为 7.4) 复溶至 50μg/ mL 的浓度。切勿涡旋。该溶液可在 2-8°C 下储存长达 1 个月。对于长期存储，建议储存温度为 -20°C。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis.
Mishra D
Molecular Biology International, 4328697-4328697 (2016)
Kiara Boodhoo et al.
Journal of molecular endocrinology, 66(2), 141-155 (2020-12-23)
Chronic wounds are a serious and debilitating complication of diabetes. A better understanding of the dysregulated healing responses following injury will provide insight into the optimal time frame for therapeutic intervention. In this study, a direct comparison was done between
Mari van de Vyver et al.
Stem cells and development, 30(23), 1141-1152 (2021-06-17)
Monitoring wound progression over time is a critical aspect for studies focused on in-depth molecular analysis or on evaluating the efficacy of potential novel therapies. Histopathological analysis of wound biopsies can provide significant insight into healing dynamics, yet there is
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SRP6450-10UG | 04061837306037 |