SRP6507
Haptoglobin (Phenotype 1-1) from human plasma
≥95% (SDS-PAGE)
别名:
Hp 1-1
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
86 kDa
General description
Haptoglobin is a positive acute-phase plasma α2-sialoglycoprotein, and exists as three major phenotypes namely Hp 1-1, Hp 2-1, and Hp 2-2. Haptoglobin is composed of heavy β- (40 kDa) and light α- (α1= 8.9kDa and α2= 16kDa) chains. Hp 1-1 is the smallest phenotype with a molecular weight of 86kDa, and is composed of only α1.
Biochem/physiol Actions
Haptoglobin functions as an antioxidant by binding free hemoglobin, and eliminates it from circulation to prevent iron loss and renal injury following hemolysis. It is responsible for maintaining the helper T-cell type 1 and type 2 (Th1/Th2) balance, and functions as an immunosuppressor of lymphocyte function. It also functions as an angiogen and anti-inflammatory agent. Hp 1-1 phenotype is most effective in binding free hemoglobin and preventing inflammatory responses linked with free hemoglobin. Studies show that all the three phenotypes of haptoglobin are involved in idiopathic generalized epilepsy.
Physical form
Lyophilized as a salt-free solid.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
Haptoglobin phenotypes in epilepsy.
Sadrzadeh SM, et al.
Clinical Chemistry, 50(6), 1095-1097 (2004)
Determination of haptoglobin genotype in an Iranian population with idiopathic generalized epilepsy.
Al-Balaghee S et al
Reports of Biochemistry and Molecular Biology, 3(2), 51-55 (2015)
Haptoglobin phenotypes in health and disorders.
Sadrzadeh SM, Bozorgmehr J, et al.
American Journal of Clinical Pathology, 121, S97-104 (2004)
Fabiana Baganha et al.
International journal of molecular sciences, 23(21) (2022-11-12)
Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in atherosclerosis, due to its atherogenic and proinflammatory effects. PC can be cleared by natural IgM antibodies and low levels of these antibodies have been associated with
Amrita Sharma et al.
iScience, 25(11), 105302-105302 (2022-10-29)
NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell perturbome workflow that compares NEU-4438's molecular modes of action
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持