Haptoglobin (Phenotype 2-2) from human plasma

Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.

Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.

Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.

Lyophilized as a salt-free solid.