SRP6539
NQO1 人
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
别名:
DT-黄递酶（DTD）, Disphorase-4（DIA4）, NAD(P)H醌氧化还原酶, NAD（P）H脱氢酶（奎宁）1（NQO1）, 二恶英诱导型1, 偶氮还原酶, 甲萘醌还原酶, 苯醌还原酶, 醌氧化还原酶1, 醌还原酶1 (QR1)
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关于此项目
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
~30 kDa (Human NQO1 aa 1-274 is fused at the C-terminus to a His-tag.)
packaging
pkg of 10 and 50 μg
impurities
<0.1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NQO1(1728)
General description
研究领域： 细胞信号传导。NQO1（NAD(P)H醌脱氢酶1）是一种专性双电子还原酶。它是一种细胞质同型二聚体蛋白，每个单体有一个FAD分子。该基因位于人染色体16q23上。它在组织中广泛表达。
Biochem/physiol Actions
NQO1（NAD(P)H醌脱氢酶1）以NADH或NADPH为还原辅因子，具有双香豆素抑制作用。人们认为它可以抵抗天然和外源性醌的作用。它参与将苯衍生的醌转化为毒性较小的对苯二酚，还参与苯相关的血液毒性作用。它参与了一些化疗药物和环境致癌物的还原和最终激活，如杂环胺、硝基芳香化合物和可能的香烟烟雾微粒。该基因的C609T空变异与北印度患者的乳腺癌易感性有关。NQO1在浆液性卵巢癌中表达上调，这种表达与预后不良有关，因此该基因有可能作为其生物标志物。
Physical form
0.2 μm滤过的50 mM Tris-Cl溶液，pH 8.0，含1 mM DTT。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma.
Cui X, et al.
BMC Cancer, 15:244 (2015)
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.
Dinkova-Kostova AT and Talalay P.
Archives of Biochemistry and Biophysics, 501(1), 116-123 (2010)
The C609T (Pro187Ser) Null Polymorphism of the NQO1 Gene Contributes Significantly to Breast Cancer Susceptibility in North Indian Populations: a Case Control Study.
Yadav P, et al.
Asian Pacific Journal of Cancer Prevention, 17(3), 1215-1219 (2016)
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Larson RA, et al.
Blood, 94(2), 803-807 (1999)
D Ross et al.
Chemico-biological interactions, 129(1-2), 77-97 (2001-01-13)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of
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