SRP6561
组织蛋白酶 K 活性 人
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
别名:
CTSK, CTSO, CTSO3
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Concentration:
0.5 mg/mL
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
23.5 kDa (115-329 aa)
packaging
pkg of 5 μg, pkg of 50 μg
concentration
0.5 mg/mL
technique(s)
activity assay: suitable
suitability
suitable for molecular biology
UniProt accession no.
application(s)
life science and biopharma
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CTSK(1513)
General description
组织蛋白酶K是以组织蛋白酶原K表达的，而它是组织蛋白酶K的失活酶原。组织蛋白酶K是一种溶酶体半胱氨酸蛋白酶，是木瓜蛋白酶半胱氨酸蛋白酶家族的一部分。它在破骨细胞中表达。编码该蛋白的基因定位于人染色体1q21。
Biochem/physiol Actions
组织蛋白酶K在骨吸收和重塑中可发挥作用。它具有三重螺旋胶原水解酶活性。编码该蛋白质的基因中的突变已与脓毒症相连。
Physical form
溶于含50%甘油的25 mM Na2HPO4和500 mM NaCl (pH 7.0)的0.5 mg/mL溶液中。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Increased Circulating Cathepsin K in Patients with Chronic Heart Failure.
Zhao G, et al.
PLoS ONE, 10(8), e0136093-e0136093 (2015)
Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease.
Bobillo L J, et al.
Medicina clinica, 145(7), 281-287 (2015)
A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin.
Huang X, et al.
Calcified Tissue International, 96(5), 373-378 (2015)
Diana J Leeming et al.
BMC cancer, 8, 180-180 (2008-07-01)
Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of the present study was to determine whether
Autocatalytic activation of human cathepsin K.
McQueney M S, et al.
The Journal of Biological Chemistry, 272(21), 13955-13960 (1997)
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