SRP8001
Calreticulin human
recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
别名:
CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
>90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~55 kDa by SDS-PAGE
产品名称
Calreticulin human, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
biological source
human
recombinant
expressed in E. coli
tag
His tagged
assay
>90% (SDS-PAGE)
form
liquid
mol wt
~55 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
calcium flux assay: suitable
impurities
<1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CALR(811)
General description
Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.
Other Notes
Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.
Physical form
Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.
Application
Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca2+ entry pathway.
Biochem/physiol Actions
Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Type 1 versus Type 2 calreticulin mutations in essential thrombocythemia: a collaborative study of 1027 patients
Ayalew Tefferi
American Journal of Hematology, 89 (2014)
Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin ?1.
Yamamoto M
Endocrinology (2017)
CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis
Elisa Rumi
Blood, 123 (2014)
New microdeletion and microduplication syndromes: a comprehensive review
Julian Nevado
Genetics and Molecular Biology (2014)
Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells*
Sic. L. Chan
The Journal of Biological Chemistry (2006)
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