SRP8001
Calreticulin human
recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
别名:
CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60
一般描述
Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.
应用
Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca2+ entry pathway.
生化/生理作用
Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
外形
Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.
其他说明
Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--人源产品
Type 1 versus Type 2 calreticulin mutations in essential thrombocythemia: a collaborative study of 1027 patients
Ayalew Tefferi
American Journal of Hematology, 89 (2014)
Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells*
Sic. L. Chan
The Journal of Biological Chemistry (2006)
Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin ?1.
Yamamoto M
Endocrinology (2017)
CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis
Elisa Rumi
Blood, 123 (2014)
A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.
Kollmann K
Leukemia, 31(4) (2017)
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