SRP8009
GITRL, Soluble mouse
recombinant, expressed in HEK 293 cells, FLAG® tagged, >90% (SDS-PAGE)
别名:
AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
mouse
Recombinant:
expressed in HEK 293 cells
Assay:
>90% (SDS-PAGE)
Form:
liquid
Mol wt:
~22 kDa by SDS-PAGE
Impurities:
<0.1 EU/μg endotoxin, tested
biological source
mouse
recombinant
expressed in HEK 293 cells
tag
FLAG® tagged
assay
>90% (SDS-PAGE)
form
liquid
mol wt
~22 kDa by SDS-PAGE
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
≥0.2 mg/mL
impurities
<0.1 EU/μg endotoxin, tested
color
clear
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Tnfsf18(240873)
General description
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Physical form
Solution in 10 mM glycine, pH 10.0.
Other Notes
The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable