SRP8010
GPX1 human
recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
别名:
Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1
产品名称
GPX1 human, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
biological source
human
recombinant
expressed in E. coli
tag
His tagged
assay
>90% (SDS-PAGE)
form
lyophilized
mol wt
~25 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GPX1(2876)
Biochem/physiol Actions
GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.
General description
GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.
Other Notes
Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.
Physical form
Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.
Preparation Note
Reconstitute with 100 μL deionized water.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.
Xiao BH, et al.
BioMed Research International, 2016, 3029810-3029810 (2016)
Association of polymorphisms of adiponectin gene promoter-11377C/G, glutathione peroxidase-1 gene C594T, and cigarette smoking in nonalcoholic fatty liver disease.
Zhang CX, et al.
Journal of the Chinese Medical Association : JCMA, 79, 195-195 (2016)
Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians.
Donadio JL, et al.
Nutrients, 8, E81-E81 (2016)
Manon Ros et al.
Nature cell biology, 22(11), 1371-1381 (2020-10-21)
Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show
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