SRP8012
Jagged-1（人）：FC（人）
recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)
别名:
JAG1, Tweak-受体, hJ1, 蛋白质jagged-1
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
>90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
~150 kDa by SDS-PAGE
产品名称
Jagged-1（人）：FC（人）, recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)
biological source
human
recombinant
expressed in HEK 293 cells
assay
>90% (SDS-PAGE)
form
liquid
mol wt
~150 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
≥0.2 mg/mL
technique(s)
ligand binding assay: suitable
impurities
<0.1 EU/μg endotoxin, tested
suitability
suitable for molecular biology
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... JAG1(182)
Application
Jagged-1已用于激活Notch1信号通路，该通路可调节心脏AMPK（5′ AMP激活的蛋白激酶）信号级联反应。Jagged-1（人）：FC（人）已用于确定工作心脏模型中的心脏底物（脂肪酸和葡萄糖）代谢。
Biochem/physiol Actions
编码的蛋白质是Notch家族受体的跨膜型配体，能够诱导Notch信号传导，从而参与胚胎发生、组织再生和癌变。Jagged-1是Wnt依赖性Notch信号激活剂，参与维持干细胞和祖细胞的稳态。锯齿状蛋白被发现与发育和癌变有关。在宫颈癌和乳腺癌中已观察到Jagged-1的过表达。
General description
Jagged-1是多个Notch受体的配体，并参与Notch信号的介导。它参与造血过程中的细胞命运决定。参与哺乳动物心血管发育的早期和晚期。抑制成肌细胞分化。增强成纤维细胞生长因子诱导的血管生成（体外）。Jagged-1中的缺陷是1型Alagille综合征（ALGS1）和法洛四联症（TOF）的原因。
由基因JAG1编码的Jagged-1是在脊椎动物中发现的锯齿状同源物。它由原始和成熟的人类造血细胞表达。编码的蛋白质包含EGF（表皮生长因子）重复序列，跨膜结构域和介于两者之间的富含半胱氨酸的区域。
Other Notes
信号肽和人Jagged-1（HJ1；CD339）（aa 1-1067）的胞外域在C末端与人IgG1的Fc部分融合。
Physical form
溶于PBS中。
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
B Varnum-Finney et al.
Blood, 91(11), 4084-4091 (1998-05-30)
We examined the expression of two members of the Notch family, Notch-1 and Notch-2, and one Notch ligand, Jagged-1, in hematopoietic cells. Both Notch-1 and Notch-2 were detected in murine marrow precursors (Lin-Sca-1+c-kit+). The Notch ligand, Jagged-1, was not detected
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells.
Katoh M and Katoh M
International Journal of Molecular Medicine, 17, 681-685 (2006)
Hui Yang et al.
Biochemical pharmacology, 108, 47-57 (2016-03-27)
AMP-activated protein kinase (AMPK) signaling pathway plays a pivotal role in intracellular adaptation to energy stress during myocardial ischemia. Notch1 signaling in the adult myocardium is also activated in response to ischemic stress. However, the relationship between Notch1 and AMPK
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.
Purow BW
Cancer Research, 65, 2353-2363 (2005)
The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells.
Karanu FN
The Journal of Experimental Medicine, 192, 1365-1372 (2000)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持