SRP8026
Annexin V human
recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)
别名:
Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I
生物来源
human
重组
expressed in E. coli
标签
GST tagged
方案
≥95% (SDS-PAGE)
表单
lyophilized
分子量
~52 kDa
包装
pkg of 100 μg
储存条件
avoid repeated freeze/thaw cycles
技术
activity assay: suitable
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... ANXA5(308)
一般描述
Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.
应用
Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).
生化/生理作用
Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.
外形
Lyophilized from PBS, pH 7.4.
制备说明
Reconstitute with 100 μL deionized water.
其他说明
Recombinant human annexin V fused to a GST-tag.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
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The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally. The role of mutant RAS in this differentiation blockade is
Xuerui Zhang et al.
Oncotarget, 8(26), 42602-42612 (2017-04-14)
Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of
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