生物来源
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
方案
>95% (SDS-PAGE)
表单
lyophilized
分子量
~50 kDa by SDS-PAGE
包装
pkg of 10 μg
杂质
<0.01 EU/μg endotoxin, tested
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)
一般描述
编码的鞭毛蛋白丝含有55 kDa单体。
鞭毛蛋白（FliC）是一种亚单位蛋白，它聚合形成细菌鞭毛丝。蛋白质有四个结构域（D0、D1、D2、D3）。
生化/生理作用
它还刺激促炎介质的产生：一氧化氮、白细胞介素1 （IL-1）、IL-6、IL-8和肿瘤坏死因子α。
鞭毛蛋白（FliC）能通过TLR5（toll样受体5）激活先天免疫系统，是一种重要的促炎分子。FliC还诱导抗体的产生，并被CD4+ T细胞鉴定为抗原。
外形
自PBS冻干。
制备说明
用100 μL去离子水重组。
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
Zeng H, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 290(1), G96-G108 (2006)
Laís Rossi Perazza et al.
The Journal of nutrition, 150(10), 2673-2686 (2020-09-05)
Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear. We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted.
Cummings LA
Molecular Microbiology, 61, 795-809 (2006)
Mucosal administration of flagellin induces innate immunity in the mouse lung.
Honko A N and Mizel S B
Infection and Immunity, 72(11), 6676-6679 (2004)
FliC-specific CD4+ T cell responses are restricted by bacterial regulation of antigen expression.
Cummings LA
Journal of Immunology, 174, 7929-7938 (2005)
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