产品名称
LAG-3 (mouse): FC (mouse), recombinant, expressed in CHO cells, >95% (SDS-PAGE)
biological source
mouse
recombinant
expressed in CHO cells
assay
>95% (SDS-PAGE)
form
liquid
mol wt
monomer ~180 kDa by SDS-PAGE (non-reducing)
monomer ~80 kDa by SDS-PAGE (reducing)
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
≥0.2 mg/mL
impurities
<1 EU/μg endotoxin, tested
color
clear
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Lag3(16768)
General description
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Other Notes
The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).
Physical form
Solution in PBS.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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