SRP8047
Omentin human
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
别名:
ACRP30headless:TNFSF13, Endothelial lectin HL-1, Galactofuranose-binding Lectin, Intestinal lactoferrin receptor, Omentin 1
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关于此项目
Form:
lyophilized
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in CHO cells
Mol wt:
~38 kDa
biological source
human
recombinant
expressed in CHO cells
tag
FLAG® tagged
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~38 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
ligand binding assay: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ITLN1(55600)
General description
Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.
Application
Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.
Biochem/physiol Actions
Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues. It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders. It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 100 μL deionized water.
Other Notes
Human omentin (aa 17-313) is fused at the N-terminus to a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
Hatzios SK
Nature Chemical Biology, 12(4), 268-274 (2016)
Michael Sigal et al.
Nature cell biology, 21(7), 812-823 (2019-06-27)
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to an increase in proliferation of Wnt-responsive
Dan Li et al.
Oncotarget, 6(18), 16168-16182 (2015-05-13)
Recent evidence shows the emerging roles of intelectin 1 (ITLN1), a secretory lectin, in human cancers. Our previous studies have implicated the potential roles of ITLN1 in the aggressiveness of gastric cancer. Herein, we investigated the functions, downstream targets, and
Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer.
Shen XD
Cytokine, 77, 50-55 (2016)
Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer.
Li D
Oncotarget, 6(18), 16168-16182 (2015)
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