SRP8049
骨膜蛋白小鼠
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
别名:
OSF-2, Osteoblast-specific factor 2, PC cell-derived growth factor
产品名称
骨膜蛋白小鼠, recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
biological source
mouse
recombinant
expressed in CHO cells
tag
FLAG® tagged
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~85 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Postn(50706)
Biochem/physiol Actions
Periostin (POSTN) participates in collagen fibrillogenesis. It plays a major role in the development of scar after traumatic spinal cord injury (SCI). Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis. It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.
General description
Periostin (POSTN) is also called as osteoblast-specific factor 2. It is a matricellular protein, located in the alveolar walls. This gene is located on human chromosome 13q13.
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
Other Notes
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 100 μL deionized water.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Periostin deficiency causes severe and lethal lung injury in mice with bleomycin administration.
Kondoh H, et al.
The Journal of Histochemistry and Cytochemistry, 64(7), 441-453 (2016)
Kai-Wen Yu et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 117(4), 292-300 (2018-01-08)
Appropriate mechanical stress plays an important role in regulating the proliferation and differentiation of osteoblasts, whereas high-level mechanical stress may be harmful and compromise cell survival. Periostin, a matricellular protein, is essential in maintaining functional integrity of bone and collagen-rich
Stefan Palme et al.
Clinical biochemistry, 50(3), 139-144 (2016-10-12)
The multifunctional cytokine IL-13 is thought to play a central role in Type 2 inflammation in asthma. Serum periostin has been explored as a candidate biomarker for evaluating IL-13 activity in the airway. We describe the technical performance characteristics of
Linkage analysis of genetic loci for kyphoscoliosis on chromosomes 5p13, 13q13. 3, and 13q32.
Miller NH, et al.
American Journal of Human Genetics, 140(10), 1059-1068 (2006)
Seong-Joon Koh et al.
PloS one, 11(2), e0149652-e0149652 (2016-02-20)
Periostin is a matricellular protein that interacts with various integrin molecules on the cell surface. Although periostin is expressed in inflamed colonic mucosa, its role in the regulation of intestinal inflammation remains unclear. We investigated the role of periostin in
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