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Merck
CN

T0195

Sigma-Aldrich

α-Bungarotoxin-tetramethylrhodamine

from Bungarus multicinctus (Formosan Banded Krait), Nicotinic acetylcholine receptor antagonist

别名:

TMR-α-BTX

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关于此项目

MDL编号:
UNSPSC代码:
12352116
NACRES:
NA.77
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产品名称

α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus (Formosan Banded Krait),

分子量

~8,500

质量水平

颜色

red

溶解性

H2O: soluble

储存温度

−20°C

应用

α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus was used at a dilution of 1:220 to identify the distribution of nicotinic acetylcholine receptors at neuromuscular junctions of longitudinal sections of rat gastrocnemius muscle.
α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus (Formosan Banded Krait) has been used in immunofluorescence staining (1:200) for identification of neuromuscular junction in experimental models. It has also been used to block muscle contraction in myotome cells.

生化/生理作用

α-Bungarotoxin is a high-affinity antagonist for nicotinic acetylcholine receptors (AChRs) from muscle but not the neurons. Labeling α-Bungarotoxin with tetramethylrhodamine enables the detection of bungarotoxin-binding receptors at neuromuscular junctions.
Useful for detecting the distribution of nicotinic acetylcholine receptors at neuromuscular junctions.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Anna L Gray et al.
Disease models & mechanisms, 13(5) (2020-03-11)
Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's Disease, is a late-onset X-linked progressive neuromuscular disease, which predominantly affects males. The pathological hallmarks of the disease are selective loss of spinal and bulbar motor neurons, accompanied by weakness
S Rakhilin et al.
The Journal of cell biology, 146(1), 203-218 (1999-07-14)
Neuronal nicotinic alpha7 subunits assemble into cell-surface complexes that neither function nor bind alpha-bungarotoxin when expressed in tsA201 cells. Functional alpha-bungarotoxin receptors are expressed if the membrane-spanning and cytoplasmic domains of the alpha7 subunit are replaced by the homologous regions
Brian T Feeley et al.
The American journal of sports medicine, 48(11), 2660-2668 (2020-07-31)
The muscle quality of the rotator cuff (RC), measured by atrophy and fatty infiltration (FI), is a key determinant of outcomes in RC injury and repair. The ability to regenerate muscle after repair has been shown to be limited. To
Sara Bachiller et al.
Molecular neurobiology, 55(12), 8856-8868 (2018-04-01)
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) mice. Recently, we have shown that before cerebellar degeneration takes place, the tbl mouse suffers from a reduction in the number of
Young-Tae Kim et al.
Biomaterials, 29(21), 3117-3127 (2008-05-02)
Peripheral nerve regeneration across long nerve gaps is clinically challenging. Autografts, the standard of therapy, are limited by availability and other complications. Here, using rigorous anatomical and functional measures, we report that aligned polymer fiber-based constructs present topographical cues that

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