T0251
胸腺嘧啶核苷5′-三磷酸 钠盐
≥96%
别名:
TTP, dTTP
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关于此项目
经验公式（希尔记法）:
C10H16N2O14P3Na
化学文摘社编号:
分子量:
504.15
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
胸腺嘧啶核苷5′-三磷酸 钠盐, ≥96%
质量水平
方案
≥96%
运输
dry ice
储存温度
−20°C
SMILES字符串
[NaH].[P](=O)(O[P](=O)(OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C)O)(O[P](=O)(O)O)O
InChI
1S/C10H17N2O14P3.Na.H/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;
InChI key
KAELIXTVSANDSE-UHFFFAOYSA-N
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应用
5′胸苷三磷酸钠盐可用于：
- 基于多适体氧化石墨烯纳米片复合物的双适体淬灭能力实验和多核苷酸检测
- 研究大肠杆菌中心代谢中的蛋白质-代谢物相互作用
- 以AM-toxin为引物，合成聚合物链式反应(PCR)产物
胸腺嘧啶核苷 5′-三磷酸（dTTP）是四种天然脱氧核苷酸之一，与脱氧腺苷 5′-三磷酸（dATP）、脱氧鸟苷 5′-三磷酸（dGTP）和脱氧胞嘧啶 5′-三磷酸（dCTP）一起通过DNA聚合酶和逆转录酶用于脱氧核糖核酸的生物合成。脱氧-TTP 也可用作研究胸苷-三磷酸酶（EC 3.6.1.39）和其他 dTTP 水解活性的特异性和动力学的底物。
生化/生理作用
胸苷三磷酸是DNA的结构单元。可作为其他核苷酸代谢的异构调节蛋白。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Interconversion of deoxyribonucleotides
Henderson JF and A.R.P.Paterson
Nucleosides, 247-259 (2018)
Felicitas Rataj et al.
Molecular biology of the cell, 27(24), 3841-3854 (2016-10-07)
TPA-inducible sequence 11b/butyrate response factor 1 (TIS11b/BRF1) belongs to the tristetraprolin (TTP) family of zinc-finger proteins, which bind to mRNAs containing AU-rich elements in their 3'-untranslated region and target them for degradation. Regulation of TTP family function through phosphorylation by
Zhuangsheng Liu et al.
Journal of magnetic resonance imaging : JMRI, 50(3), 847-857 (2019-02-19)
Lymphovascular invasion (LVI) status facilitates the selection of optimal therapeutic strategy for breast cancer patients, but in clinical practice LVI status is determined in pathological specimens after resection. To explore the use of dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI)-based radiomics
Xue-Ke Zhao et al.
PloS one, 11(12), e0167451-e0167451 (2016-12-03)
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has
Merel M C Lambregts et al.
PloS one, 14(1), e0208819-e0208819 (2019-01-03)
Blood cultures are considered the gold standard to distinguish bacteremia from non-bacteremic systemic inflammation. In current clinical practice, bacteraemia is considered unlikely if blood cultures have been negative for 48-72 hours. Modern BC systems have reduced this time-to-positivity (TTP), questioning
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