T0251
胸腺嘧啶核苷5′-三磷酸 钠盐
≥96%
别名:
TTP, dTTP
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关于此项目
经验公式（希尔记法）:
C10H16N2O14P3Na
化学文摘社编号:
分子量:
504.15
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
胸腺嘧啶核苷5′-三磷酸 钠盐, ≥96%
SMILES string
[NaH].[P](=O)(O[P](=O)(OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C)O)(O[P](=O)(O)O)O
InChI
1S/C10H17N2O14P3.Na.H/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;
InChI key
KAELIXTVSANDSE-UHFFFAOYSA-N
assay
≥96%
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Application
5′胸苷三磷酸钠盐可用于：
- 基于多适体氧化石墨烯纳米片复合物的双适体淬灭能力实验和多核苷酸检测
- 研究大肠杆菌中心代谢中的蛋白质-代谢物相互作用
- 以AM-toxin为引物，合成聚合物链式反应(PCR)产物
胸腺嘧啶核苷 5′-三磷酸（dTTP）是四种天然脱氧核苷酸之一，与脱氧腺苷 5′-三磷酸（dATP）、脱氧鸟苷 5′-三磷酸（dGTP）和脱氧胞嘧啶 5′-三磷酸（dCTP）一起通过DNA聚合酶和逆转录酶用于脱氧核糖核酸的生物合成。脱氧-TTP 也可用作研究胸苷-三磷酸酶（EC 3.6.1.39）和其他 dTTP 水解活性的特异性和动力学的底物。
Biochem/physiol Actions
胸苷三磷酸是DNA的结构单元。可作为其他核苷酸代谢的异构调节蛋白。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Maria Eugenia Davola et al.
Methods in enzymology, 635, 231-250 (2020-03-04)
Among the many immunotherapies being developed and tested both preclinically and clinically, oncolytic viruses (OVs) are gaining traction as a forerunner in the search for potent new therapeutic agents, with a genetically engineered herpes simplex virus type 1 (HSV-1) recently
Christina Jensen et al.
Scientific reports, 7(1), 2830-2830 (2017-06-08)
In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro. We optimised a reproducible murine splenocyte MGIA based on
Interconversion of deoxyribonucleotides
Henderson JF and A.R.P.Paterson
Nucleosides, 247-259 (2018)
Merel M C Lambregts et al.
PloS one, 14(1), e0208819-e0208819 (2019-01-03)
Blood cultures are considered the gold standard to distinguish bacteremia from non-bacteremic systemic inflammation. In current clinical practice, bacteraemia is considered unlikely if blood cultures have been negative for 48-72 hours. Modern BC systems have reduced this time-to-positivity (TTP), questioning
Xue-Ke Zhao et al.
PloS one, 11(12), e0167451-e0167451 (2016-12-03)
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has
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