T0452
D-α-生育三烯酚
from rice, ≥75% (GC)
别名:
3,4-二氢-2,5,7,8-四甲基-2-（4,8,12-三甲基-3,7,11-十三碳三烯基）-2H-1-苯并吡喃-6-醇
SMILES string
O1[C@@](CCc2c1c(c(c(c2C)O)C)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
InChI
1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
InChI key
RZFHLOLGZPDCHJ-XZXLULOTSA-N
biological source
rice
assay
≥75% (GC)
form
liquid
color
colorless to brown
mp
30-31 °C
storage temp.
−20°C
Quality Level
General description
生育三烯酚属于维生素E家族，具有不饱和类异戊二烯侧链。生育三烯酚的各种同种型在色原烷醇中的甲基取代基不同。α-粗棕榈油中的生育三烯酚是一种天然的补充剂。
Biochem/physiol Actions
α-生育三烯酚可与其他同种型一起使用以区分生育三烯酚活性。
α-生育三烯酚是一种有效的自由基清除剂，它在微粒体的氧化应激过程中引发保护功能。它是一种强效抗氧化剂，可减少炎症并用于癌症治疗。α-补充生育三烯酚可以降低高胆固醇血症中的胆固醇水平。α-生育三烯酚具有神经保护作用，因为它可阻止谷氨酸盐诱导的神经元细胞死亡。
生育三烯酚因其强抗氧化属性而被广泛使用。生育三烯酚的不同亚型在色满醇头的甲基取代上有所不同。α-生育三烯酚通过阻断神经元细胞中谷氨酸诱导的细胞死亡而表现出神经保护属性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
Packer L, et al.
The Journal of Nutrition, 131(2), 369S-373S (2001)
Vladimir Gogvadze et al.
International journal of cancer, 127(8), 1823-1832 (2010-01-28)
Release of mitochondrial proteins such as cytochrome c, AIF, Smac/Diablo etc., plays a crucial role in apoptosis induction. A redox-silent analog of vitamin E, alpha-tocopheryl succinate (alpha-TOS), was shown to stimulate cytochrome c release via production of reactive oxygen species
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice
Qureshi AA, et al.
Lipids in Health and Disease, 9(1), 143-143 (2010)
Tomono Uchida et al.
Lipids, 47(2), 129-139 (2011-11-02)
The aim of this study was to evaluate tissue distribution of vitamin E isoforms such as α- and γ-tocotrienol and γ-tocopherol and interference with their tissue accumulation by α-tocopherol. Rats were fed a diet containing a tocotrienol mixture or γ-tocopherol
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Ramanathan N, et al.
Nutrition & Metabolism, 15(1), 6-6 (2018)
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