T0656
1,3,4,6-四氯-3α,6α-二苯基甘脲
别名:
Iodo-Gen®, NSC 4462
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关于此项目
经验公式（希尔记法）:
C16H10Cl4N4O2
化学文摘社编号:
分子量:
432.09
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
InChI
1S/C16H10Cl4N4O2/c17-21-13(25)23(19)16(12-9-5-2-6-10-12)15(21,11-7-3-1-4-8-11)22(18)14(26)24(16)20/h1-10H
SMILES string
ClN1C(=O)N(Cl)C2(N(Cl)C(=O)N(Cl)C12c3ccccc3)c4ccccc4
InChI key
FJQZXCPWAGYPSD-UHFFFAOYSA-N
storage temp.
2-8°C
Quality Level
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Application
用作氧化剂的放射性碘化用碘化试剂
用于氯胺-T 比较研究的试剂
用于氧化咪唑的试剂
用于氯胺-T 比较研究的试剂
用于氧化咪唑的试剂
Legal Information
Iodo-Gen is a registered trademark of Pierce Biotechnology, Inc.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
M R Zalutsky et al.
Nuclear medicine and biology, 26(7), 781-790 (2000-01-11)
Monoclonal antibody (MAb) internalization can have a major effect on tumor retention of radiolabel. Two anti-HER-2/neu MAbs (TA1 and 520C9) were radioiodinated using the iodogen, N-succinimidyl 5-iodo-3-pyridinecarboxylate (SIPC), and tyramine-cellobiose (TCB) methods. Paired-label studies compared internalization and cellular processing of
P K Garg et al.
Bioconjugate chemistry, 7(2), 233-239 (1996-03-01)
Two peptides of potential utility for targeting melanoma cells, alpha-melanocyte-stimulating hormone (alpha-MSH) and its more potent analogue [Nle4,D-Phe7]-alpha-MSH, were radioiodinated in 45-65% yield using N-succinimidyl 3-[125I]iodobenzoate (SIB). To determine whether this labeling method resulted in improved in vitro and in
E Carnazzi et al.
Journal of medicinal chemistry, 37(12), 1841-1849 (1994-06-10)
A series of new linear photoactivatable and iodinatable antagonists of the neuropeptidic hormone vasopressin was designed and synthesized by a combination of PyBOP-mediated Boc/solid-phase peptide synthesis and solution synthesis approaches. These were based on modifications of a previously reported potent
G W Visser et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 42(3), 509-519 (2001-05-05)
A novel, facile procedure for efficient coupling of high doses of (131)I to monoclonal antibodies (MAbs) was developed with minimal chemical and radiation damage. To diminish the radiation and chemical burden during labeling, iodination was performed in a large reaction
P K Garg et al.
Bioconjugate chemistry, 6(4), 493-501 (1995-07-01)
The F(ab')2 fragment of monoclonal antibody (MAb) Me1-14 was labeled with 125I using the Iodogen method and by reaction with N-succinimidyl 3-[125I]iodobenzoate (SIB). The labeled catabolites generated after exposure to tissue homogenates in vitro and following administration of labeled F(ab')2
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