T122
Telenzepine dihydrochloride hydrate
solid, ≥98% (HPLC)
别名:
4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
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关于此项目
经验公式（希尔记法）:
C19H22N4O2S · 2HCl · xH2O
化学文摘社编号:
分子量:
443.39 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C19H22N4O2S.2ClH.H2O/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22;;;/h3-6,12H,7-11H2,1-2H3,(H,20,25);2*1H;1H2
SMILES string
O.Cl.Cl.CN1CCN(CC1)CC(=O)N2c3ccccc3NC(=O)c4csc(C)c24
InChI key
HZWCRPGARSMPNS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: >10 mg/mL
Quality Level
Gene Information
human ... CHRM1(1128)
Application
Telenzepine dihydrochloride hydrate was used to study M1 muscarinic receptor-mediated signaling in juvenile rat hippocampus and rat urinary bladder.
Biochem/physiol Actions
Telenzepine is an analog of pirenzepine and inhibits the secretion of gastric acid. It is an antagonist to M1-receptor and targets the oxyntic gastric glands and the salivary glands.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
K Kawashima et al.
General pharmacology, 21(1), 17-21 (1990-01-01)
1. Effects of three muscarinic antagonists on electrically evoked ACh release and contractile response were investigated in longitudinal muscle strips of guinea-pig ileum suspended in an organ-bath and superfused with Krebs solution. ACh release was determined by a specific radioimmunoassay.
G Coruzzi et al.
Archives internationales de pharmacodynamie et de therapie, 302, 232-241 (1989-11-01)
The new M1-receptor antagonist telenzepine has been studied for its antisecretory effect in different in vitro and in vivo experimental models in comparison with pirenzepine. Telenzepine was found to be from 3 to 10 times more potent than pirenzepine in
G Bertaccini et al.
Pharmacological research, 21(4), 339-352 (1989-07-01)
The control of gastric secretion may be obtained by means of several pharmacological compounds: histamine H2 receptor antagonists and anticholinergics are so far the most widely employed drugs in pharmacological experiments and in clinical practice. The H2 blockers are able
Turgut Emrah Bozkurt et al.
Pharmacological research, 59(5), 300-305 (2009-05-07)
We have investigated the muscarinic receptor subtype(s) mediating the release of urinary bladder-derived relaxant factor that is demonstrated by a coaxial bioassay system. Acetylcholine-induced relaxation of a precontracted anococcygeus muscle mounted within the bladder was considered as an evidence for
A M Rosati et al.
Brain research, 815(2), 185-191 (1999-01-08)
Binding studies were used to assess the changes in affinity and/or number of M1 muscarinic receptors in hippocampi from juvenile rats chronically deprived of NGF. NGF deprivation was obtained by implanting into right ventricle at postnatal day 2 (P2) hybrydoma
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