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文件

T1270

硫胺盐酸盐

Name: 硫胺 盐酸盐
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

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别名:

硫胺素盐酸盐, 维生素 B ₁ 盐酸盐

经验公式（希尔记法）:

C₁₂H₁₇ClN₄OS · HCl

CAS号:

67-03-8

分子量:

337.27

Beilstein:

3851771

EC 号:

200-641-8

MDL编号:

MFCD00012780

eCl@ss:

34058006

PubChem化学物质编号:

24899952

NACRES:

NA.75

生物来源

synthetic (organic)

质量水平

200

产品线

BioReagent

检测方案

≥99.0% (HPLC)

形式

powder

分子量

M_w 337.27 g/mol

技术

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

颜色

white

mp

250 °C (dec.) (lit.)

溶解性

H₂O: 50 mg/mL, clear, colorless

应用

agriculture

SMILES字符串

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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一般描述

硫胺素或维生素B1带正电荷，是所有组织的基本成分。它在骨骼肌、肝脏、肾脏、心脏和大脑中含量较高。硫胺素由一个嘧啶环组成，通过亚甲基桥连接到一个噻唑环。

应用

盐酸硫胺素已被用作以下物质的组分：

维生素浓缩原液，用于制备培养火山富盐菌的Hv-Ca培养基
三乙酸磷酸盐（TAP）培养基，用于培养雪衣藻
改良Bold 3N培养基，用于培养小球藻

生化/生理作用

硫胺素通过硫胺素二磷酸激酶进入细胞膜后转化为二磷酸硫胺素。二磷酸硫胺素是一种活性辅因子，对于许多酶的机制至关重要，这些酶参与柠檬酸循环、糖酵解途径、支链氨基酸降解和磷酸戊糖通路。硫胺素参与将食物转化为能量的过程，供中枢和外周神经系统运作使用。该维生素的低水平与谵妄、Wernicke脑病和Wernicke-Korsakoff综合征有关。盐酸硫胺素是培养细胞能量代谢和氨基酸合成所必需的。它存在于许多经典和无血清配方中。

象形图

GHS07

警示用语：

Warning

危险声明

H319

预防措施声明

P264 - P280 - P305 + P351 + P338 - P337 + P313

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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示例

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货号

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包装规格/数量

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Cinzia Fino et al.

MicrobiologyOpen, 9(8), e1064-e1064 (2020-06-20)

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Scientific reports, 10(1), 9620-9620 (2020-06-17)

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Improved growth and morphological plasticity of Haloferax volcanii.

Roshali T de Silva et al.

Microbiology (Reading, England), 167(2) (2021-01-19)

Some microbes display pleomorphism, showing variable cell shapes in a single culture, whereas others differentiate to adapt to changed environmental conditions. The pleomorphic archaeon Haloferax volcanii commonly forms discoid-shaped ('plate') cells in culture, but may also be present as rods

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硫胺 盐酸盐