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T1284

Calcitonin eel

≥97% (HPLC)

别名:

Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 [Disulfide bridge: 1–7], Thyrocalcitonin Eel

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关于此项目

经验公式（希尔记法）:
C146H241N43O47S2
化学文摘社编号:
57014-02-5
分子量:
3414.87
UNSPSC Code:
12352200
PubChem Substance ID:
24899953
MDL number:
MFCD00133858
Form:
solid
Assay:
≥97% (HPLC)
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assay

≥97% (HPLC)

form

solid

UniProt accession no.

P22387

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(NC(=O)C1CSSCC(N)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)N1)C(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(C(C)O)C(=O)NC(Cc3ccc(O)cc3)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(C)C(=O)NCC(=O)NC(C(C)O)C(=O)N5CCCC5C(N)=O

InChI

1S/C146H241N43O47S2/c1-66(2)47-88(175-140(231)112(72(13)14)184-137(228)100-64-238-237-63-81(149)119(210)178-97(60-190)135(226)174-94(54-105(152)200)132(223)172-92(51-70(9)10)130(221)180-99(62-192)136(227)187-115(76(18)195)143(234)181-100)120(211)159-58-107(202)163-82(27-20-22-42-147)121(212)169-91(50-69(7)8)129(220)179-98(61-191)134(225)167-85(36-39-103(150)198)123(214)165-87(38-41-109(204)205)124(215)171-90(49-68(5)6)128(219)173-93(53-79-56-156-65-161-79)131(222)164-83(28-21-23-43-148)122(213)170-89(48-67(3)4)127(218)166-86(37-40-104(151)199)126(217)186-114(75(17)194)142(233)177-96(52-78-32-34-80(197)35-33-78)144(235)189-46-26-31-102(189)138(229)168-84(29-24-44-157-146(154)155)125(216)185-113(74(16)193)141(232)176-95(55-110(206)207)133(224)183-111(71(11)12)139(230)160-57-106(201)162-73(15)118(209)158-59-108(203)182-116(77(19)196)145(236)188-45-25-30-101(188)117(153)208/h32-35,56,65-77,81-102,111-116,190-197H,20-31,36-55,57-64,147-149H2,1-19H3,(H2,150,198)(H2,151,199)(H2,152,200)(H2,153,208)(H,156,161)(H,158,209)(H,159,211)(H,160,230)(H,162,201)(H,163,202)(H,164,222)(H,165,214)(H,166,218)(H,167,225)(H,168,229)(H,169,212)(H,170,213)(H,171,215)(H,172,223)(H,173,219)(H,174,226)(H,175,231)(H,176,232)(H,177,233)(H,178,210)(H,179,220)(H,180,221)(H,181,234)(H,182,203)(H,183,224)(H,184,228)(H,185,216)(H,186,217)(H,187,227)(H,204,205)(H,206,207)(H4,154,155,157)

InChI key

JDJALSWDQPEHEJ-UHFFFAOYSA-N

Gene Information

mouse ... Edn1(13614)

Biochem/physiol Actions

Hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.

Other Notes

A 32 amino acid polypeptide, 8 of which are conserved across all species.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
077H4956
070H48452
077H49561
070H4845
070H48451

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C L H Huang et al.
Cellular and molecular biology (Noisy-le-Grand, France), 52(3), 33-43 (2007-05-31)
Calcitonin is a thirty-two amino acid peptide that contains an N-terminal disulphide bridge and a C-terminal prolineamide residue. It is released from thyroid parafollicular C-cells and its direct actions on the osteoclast account for its physiological effects whether as a
F J A de Paula et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 42(5), 299-306 (2010-03-11)
This review reflects on the past, present, and future of translational research on calcitropic hormones and bone metabolism. Calcitonin (CT) and parathormone (PTH) are complementary hormones involved in the acquisition and maintenance of bone mass and regulation of calcium metabolism.
S Tanaka et al.
Cellular and molecular biology (Noisy-le-Grand, France), 52(3), 19-23 (2007-05-31)
Calcitonin is a calcium-regulating peptide hormone that acts directly on osteoclasts and suppresses their function. In this review we will focus on the downstream signaling pathways of calcitonin receptor regulating cytoskeletal organization of osteoclasts. We will also introduce the clinical
D Naot et al.
Bone, 43(5), 813-818 (2008-08-09)
The 'calcitonin family' is a group of peptide hormones that share structural similarities with calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin and adrenomedullin 2 (intermedin). These hormones are produced by different tissues, with calcitonin being produced in thyroid

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