T133
Inactin® hydrate
≥98% (HPLC), Anethetic reagent, powder
别名:
Thiobutabarbital sodium salt hydrate
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关于此项目
经验公式（希尔记法）:
C10H15N2NaO2S · xH2O
化学文摘社编号:
分子量:
250.29 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-425-3
MDL number:
产品名称
Inactin® hydrate, ≥98% (HPLC)
InChI
1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1
InChI key
SLZHLQUFNFXTHB-UHFFFAOYSA-M
SMILES string
[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada
color
light yellow
solubility
H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)
Quality Level
Application
Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).
Biochem/physiol Actions
Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.
Legal Information
Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Flecknell
Laboratory Animal Anesthesia. An introduction for Research Workers and Technicians, 36-36 (1987)
Olga Rafikova et al.
Biology of sex differences, 11(1), 11-11 (2020-03-20)
The mechanisms involved in pulmonary hypertension (PH) development in patients and pre-clinical models are poorly understood. PH has a well-established sex dimorphism in patients with increased frequency of PH in females, and more severe disease with poor survival prognosis in
A C Ailiani et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(10), 1477-1486 (2014-09-27)
Anesthetics are commonly applied in animal studies of gastrointestinal (GI) function. Different anesthetics alter smooth-muscle motility in different ways. The aim of this study is to quantify and compare non-invasively with magnetic resonance imaging (MRI) the motility patterns of the
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