Anti-γ-Tubulin (LL-17) antibody produced in rabbit

γ-Tubulin is a widely expressed and highly conserved protein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells. It is a member of the tubulin superfamily of proteins, which includes α and β tubulin and the newly discovered centrosomal-associated proteins, δ and ε tubulin. γ-Tubulin abundance is less than 1% of the level of either α or β tubulin.

γTubulin (LL-17) is a widely expressed and highly conservedprotein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells.

synthetic peptide corresponding to the C-terminus of C. elegans γ-tubulin (amino acids 428-444) with N-terminal added cysteine, conjugated to KLH. This sequence is highly specific for C. elegans γ-tubulin, and not found in γ-tubulin sequences of other species or other members of the tubulin family such as α-, β-, δ-, and ε-tubulins.

Anti-γ-Tubulin (LL-17) antibody produced in rabbit has been used in immunoblotting.

γ-Tubulin has an essential role in microtubule nucleation by the centrosomes. γ-Tubulin does not polymerize with α-tubulin/β-tubulin, but instead it is localized to the centrosome and to the cytoplasm. γ-Tubulin is found as part of a large protein complex containing at least five other proteins and has a shape of a ring (γ-tubulin ring complex, γ-TuRC) that is roughly the same diameter as a microtubule. γ-Tubulin binds the microtubule minus ends and is responsible for mediating the link between microtubules and the centrosome.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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