T154
Tityustoxin-Kα from Tityus serrulatus (Brazilian scorpion) venom
lyophilized powder
表单
lyophilized powder
溶解性
H2O: soluble
储存温度
−20°C
基因信息
human ... KCNS1(3787), KCNS2(3788)
mouse ... KCNS1(16538), KCNS2(16539)
rat ... KCNS1(117023), KCNS2(66022)
Amino Acid Sequence
Val-Phe-Ile-Asn-Ala-Lys-Cys-Arg-Gly-Ser-Pro-Glu-Cys-Leu-Pro-Lys-Cys-Lys-Glu-Ala-Ile-Gly-Lys-Ala-Ala-Gly-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro
生化/生理作用
Potent and selective voltage-gated non-inactivating (delayed-rectifier) K+ channel blocker.
法律信息
Sold under license from the University of Maryland.
免责声明
Hygroscopic, photosensitive. Only plastic tubes should be used with this product.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Alessandro Grottesi et al.
FEBS letters, 535(1-3), 29-33 (2003-02-01)
Toxins that block voltage-gated potassium (Kv) channels provide a possible template for improved homology models of the Kv pore. In assessing the interactions of Kv channels and their toxins it is important to determine the dynamic flexibility of the toxins.
Adolfo Borges et al.
Parasitology research, 99(2), 167-173 (2006-03-16)
Leishmania parasites are sensitive to peptides with antimicrobial and ion-channel inhibitory activity. Because scorpion venoms are rich sources of such peptides, the leishmanicidal effect of Tityus discrepans venom was investigated. A negative correlation between cell growth and venom concentration was
Michel B S Mesquita et al.
Toxicology and applied pharmacology, 187(1), 58-66 (2003-03-12)
In this work we submitted adult male Wistar rats to intracerebroventricular (icv) and iv microinjections of the fraction tityostoxin (TsTX) from the Tityus serrulatus scorpion venom, to address whether the CNS could account for the systemic alterations previously reported: cardiac
Andréa C Pessini et al.
Toxicon : official journal of the International Society on Toxinology, 48(5), 556-566 (2006-08-17)
Tityus serrulatus venom (Tsv) was intraperitoneally (ip) injected at doses of 75, 150 and 300mug/kg and IL-1beta (2.0 microg/kg) was given intravenously (iv) to male Wistar rats. Rectal temperature was measured by radiotelemetry. Vagotomy was performed according to Bluthe et
Ana Leonor A Nencioni et al.
Pharmacology, biochemistry, and behavior, 74(2), 455-463 (2002-12-14)
Scorpion toxins act on ionic channels changing the release of neurotransmitters. In the present study, we investigated the glutamatergic release evoked by intrahippocampal injection of TsTX toxin isolated from Tityus serrulatus scorpion venom in male Wistar rats and the blockade
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持