T1573
凝血酶受体活化因子肽 6
>95% (HPLC)
别名:
TRAP-6
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关于此项目
经验公式（希尔记法）:
C34H56N10O9
化学文摘社编号:
分子量:
748.87
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
>95% (HPLC)
表单
lyophilized
技术
cell culture | mammalian: suitable
溶解性
0.1% TFA: soluble
water: soluble
UniProt登记号
储存温度
−20°C
SMILES字符串
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
InChI
1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
InChI key
HAGOWCONESKMDW-FRSCJGFNSA-N
基因信息
human ... F2R(2149)
Amino Acid Sequence
Ser-Phe-Leu-Leu-Arg-Asn
一般描述
凝血酶受体激活肽6（TRAP-6）可保护星形胶质细胞免于细胞死亡，其与低血糖症有关。在流动条件下，TRAP-6会诱导聚集并损害胶原蛋白的附着力。
应用
凝血酶受体激活物肽6已在体外被用于激活血小板。它也已被用于下调hippo信号并上调核yes相关蛋白（YAP）。
生化/生理作用
凝血酶受体的六肽片段（残基 42-47）。
凝血酶受体的六肽片段（残基 42-47）。可激活凝血酶受体并引起血小板聚集 (EC 50 = 0.8 μM)。
其他说明
从 0.1%TFA 水溶液冻干
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Kristoffer Navred et al.
PloS one, 14(1), e0211130-e0211130 (2019-01-24)
Flow cytometric platelet activation has emerged as an alternative diagnostic test for inherited platelet disorders. It is, however, labor intensive and few studies have directly compared the performance of flow cytometric platelet activation (PACT) to light transmission aggregometry (LTA). The
Hematology: Basic Principles and Practice E-Book: Basic Principles and Practice (2017)
Xavier Charest-Morin et al.
Frontiers in immunology, 9, 2183-2183 (2018-10-20)
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation.
Alberto Zanetto et al.
Cancers, 13(5) (2021-04-04)
Hyper-functional platelets are being proposed as a potential therapeutic target in multiple cancers. Whether this can be considered in patients with cirrhosis and hepatocellular carcinoma (HCC) is unknown as their platelet function has not yet been investigated. We evaluated platelet
Juergen Koessler et al.
PloS one, 12(11), e0188193-e0188193 (2017-11-21)
Platelets are important for effective hemostasis and considered to be involved in pathophysiological processes, e.g. in cardiovascular diseases. Platelets provided for research or for therapeutic use are frequently separated from citrated whole blood (WB) stored for different periods of time.
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