T1573
凝血酶受体活化因子肽 6
>95% (HPLC)
别名:
TRAP-6
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关于此项目
经验公式（希尔记法）:
C34H56N10O9
化学文摘社编号:
分子量:
748.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
lyophilized
Assay:
>95% (HPLC)
solubility
water: soluble, 0.1% TFA: soluble
InChI key
HAGOWCONESKMDW-FRSCJGFNSA-N
SMILES string
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
InChI
1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
assay
>95% (HPLC)
form
lyophilized
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... F2R(2149)
General description
凝血酶受体激活肽6（TRAP-6）可保护星形胶质细胞免于细胞死亡，其与低血糖症有关。在流动条件下，TRAP-6会诱导聚集并损害胶原蛋白的附着力。
Application
凝血酶受体激活物肽6已在体外被用于激活血小板。它也已被用于下调hippo信号并上调核yes相关蛋白（YAP）。
Biochem/physiol Actions
凝血酶受体的六肽片段（残基 42-47）。
凝血酶受体的六肽片段（残基 42-47）。可激活凝血酶受体并引起血小板聚集 (EC 50 = 0.8 μM)。
Other Notes
从 0.1%TFA 水溶液冻干
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 24(1), 179-185 (2017-03-18)
We aimed to identify the prevalence of acetylsalicylic acid (ASA) nonresponse in patients after coronary artery bypass graft (CABG) surgery and the possible consequences for the rate of major cardiovascular events. This prospective, observational, bicentric cohort study was conducted in
Xavier Charest-Morin et al.
Frontiers in immunology, 9, 2183-2183 (2018-10-20)
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation.
Chemistry and Biology of Serpins (2012)
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