T165
S(+)-特麦角脲
solid
别名:
S(+)-N,N-Diethyl-N′([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R)
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关于此项目
经验公式（希尔记法）:
C20H28N4O
化学文摘社编号:
分子量:
340.46
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
253-624-2
MDL number:
form
solid
optical activity
[α]20/D +28°, c = 0.2 in pyridine(lit.)
color
white
solubility
DMSO: soluble, H2O: insoluble, ethanol: soluble
SMILES string
[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NC(=O)N(CC)CC
Gene Information
human ... DRD2(1813)
rat ... Drd2(24318)
Biochem/physiol Actions
Ergot derivative; dehydrogenated analog of lisuride; D2 dopamine receptor partial agonist.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
T Akai et al.
Annals of neurology, 33(5), 507-511 (1993-05-01)
Behavioral effects of terguride, a partial dopamine D2 agonist, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys were compared with those of the dopamine agonist apomorphine and the dopamine antagonist haloperidol. Terguride alone ameliorated the parkinsonism without inducing any sign of excitability