T1692
噻奈普汀 钠盐 水合物
≥98% (HPLC), opioid receptor agaonist, powder
别名:
7-[(3-氯-6,11-二氢-6-甲基-二苯并[c，f] [1,2]硫氮平-11-基)氨基]庚酸S,S二氧化物 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C21H24ClN2NaO4S · xH2O
化学文摘社编号:
分子量:
458.93 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
噻奈普汀 钠盐 水合物, ≥98% (HPLC), powder
SMILES string
O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O
InChI
1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1
InChI key
HNTRDGDHBBFLPG-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥20 mg/mL
originator
Servier
storage temp.
room temp
Quality Level
相关类别
General description
噻奈普汀是一种μ-阿片受体（MOR）和δ-阿片受体（DOR）激动剂。
Application
水合噻奈普汀钠盐已被用于在人胚肾293细胞系中进行的5-羟色胺转运体（SERT）测定中作为5-羟色胺再摄取增强剂（SSRE）阳性对照。
Biochem/physiol Actions
噻奈普汀是一种可增强5-羟色胺再摄取的三环类抗抑郁药。这种药物会影响到神经保护、神经兴奋性、记忆和焦虑。然而，噻奈普汀与不良的精神运动、认知、心血管、睡眠和体重影响无关。该药物具有较低的滥用倾向性，以及正向的药代动力学曲线。
噻奈普汀是最少参与到药物相互作用的，因为它并不会被肝脏中的细胞色素P450系统所代谢。在海马体和杏仁核中，噻奈普汀可参与到谷氨酸能传递过程并引起神经可塑性。
Preparation Note
噻奈普汀钠盐水合物可溶于 DMSO，浓度大于或等于 20 mg/ml。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Zorana Oreščanin-Dušić et al.
Acta physiologica Hungarica, 99(2), 140-147 (2012-08-02)
Tianeptine is a novel anti-depressant with an efficacy equivalent to that of classical anti-depressants. Additional beneficial effects include neuroprotection, anti-stress and anti-ulcer properties whose molecular mechanisms are still not completely understood but may involve changes in the anti-oxidant defence system.
C D Conrad et al.
Behavioral neuroscience, 110(6), 1321-1334 (1996-12-01)
Chronic restraint stress causes significant dendritic atrophy of CA3 pyramidal neurons that reverts to baseline within a week. Therefore, the authors assessed the functional consequences of this atrophy quickly (within hours) using the Y maze. Experiments 1-3 demonstrated that rats
Metabolic and Behavioral Effects of Serotonergic Antidepressants in Rats Exposed to Swim Endurance Stress.
Gitay, M., and Bano, S.
Journal of Basic & Applied Sciences, 9, 269-275 (2013)
N M Maksimova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(11 Pt 2), 41-47 (2012-12-22)
Peculiarities of the dynamics of anxious depression under the treatment with selective serotonergic antidepressants with different mechanisms of action on the serotonin reuptake were investigated. It was examined 61 patients with anxious depression (ICD-10 F32.1, F33.1, F34.1) treated with zoloft
Gerardo G Piroli et al.
Experimental neurology, 241, 184-193 (2012-12-25)
Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients.
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