T1692
噻奈普汀 钠盐 水合物
≥98% (HPLC), opioid receptor agaonist, powder
别名:
7-[(3-氯-6,11-二氢-6-甲基-二苯并[c，f] [1,2]硫氮平-11-基)氨基]庚酸S,S二氧化物 钠盐 水合物
Product Name
噻奈普汀 钠盐 水合物, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to tan
溶解性
DMSO: ≥20 mg/mL
创始人
Servier
储存温度
room temp
SMILES字符串
O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O
InChI
1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1
InChI key
HNTRDGDHBBFLPG-UHFFFAOYSA-M
相关类别
一般描述
噻奈普汀是一种μ-阿片受体（MOR）和δ-阿片受体（DOR）激动剂。
应用
水合噻奈普汀钠盐已被用于在人胚肾293细胞系中进行的5-羟色胺转运体（SERT）测定中作为5-羟色胺再摄取增强剂（SSRE）阳性对照。
生化/生理作用
噻奈普汀是一种可增强5-羟色胺再摄取的三环类抗抑郁药。这种药物会影响到神经保护、神经兴奋性、记忆和焦虑。然而，噻奈普汀与不良的精神运动、认知、心血管、睡眠和体重影响无关。该药物具有较低的滥用倾向性，以及正向的药代动力学曲线。
噻奈普汀是最少参与到药物相互作用的，因为它并不会被肝脏中的细胞色素P450系统所代谢。在海马体和杏仁核中，噻奈普汀可参与到谷氨酸能传递过程并引起神经可塑性。
制备说明
噻奈普汀钠盐水合物可溶于 DMSO，浓度大于或等于 20 mg/ml。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Frankfurt et al.
Brain research, 696(1-2), 1-6 (1995-10-23)
Tianeptine is an atypical tricyclic antidepressant that facilitates serotonin (5-HT) reuptake. Tianeptine (10 mg/kg) or saline was administered intraperitoneally to male rats daily for 4 days. Monoamine levels were measured in micropunches of discrete brain nuclei that are implicated in
W Sohn et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(9), 860-e398-860-e398 (2012-06-12)
Tricyclic antidepressants have good efficacy in irritable bowel syndrome with diarrhea (IBS-D), but their clinical use is limited by considerations of tolerability. Tianeptine, another antidepressant, acts as a selective serotonin reuptake enhancer. We compared tianeptine with amitriptyline for the treatment
A Sah et al.
Translational psychiatry, 2, e171-e171 (2012-10-11)
Adult neurogenesis has been implicated in affective disorders and the action of antidepressants (ADs) although the functional significance of this association is still unclear. The use of animal models closely mimicking human comorbid affective and anxiety disorders seen in the
M Teresa Donato et al.
Journal of biomolecular screening, 17(3), 394-400 (2011-11-26)
In the present study, we developed a cell-based protocol for the identification of drugs able to induce steatosis. The assay measures multiple markers of toxicity in a 96-well plate format using high-content screening (HCS) technology. After treating HepG2 cells with
Oguz Mutlu et al.
Life sciences, 91(25-26), 1252-1262 (2012-10-17)
Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of
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