T1692
噻奈普汀 钠盐 水合物
≥98% (HPLC), opioid receptor agaonist, powder
别名:
7-[(3-氯-6,11-二氢-6-甲基-二苯并[c，f] [1,2]硫氮平-11-基)氨基]庚酸S,S二氧化物 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C21H24ClN2NaO4S · xH2O
化学文摘社编号:
分子量:
458.93 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
噻奈普汀 钠盐 水合物, ≥98% (HPLC), powder
SMILES string
O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O
InChI
1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1
InChI key
HNTRDGDHBBFLPG-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥20 mg/mL
originator
Servier
storage temp.
room temp
Quality Level
相关类别
General description
噻奈普汀是一种μ-阿片受体（MOR）和δ-阿片受体（DOR）激动剂。
Application
水合噻奈普汀钠盐已被用于在人胚肾293细胞系中进行的5-羟色胺转运体（SERT）测定中作为5-羟色胺再摄取增强剂（SSRE）阳性对照。
Biochem/physiol Actions
噻奈普汀是一种可增强5-羟色胺再摄取的三环类抗抑郁药。这种药物会影响到神经保护、神经兴奋性、记忆和焦虑。然而，噻奈普汀与不良的精神运动、认知、心血管、睡眠和体重影响无关。该药物具有较低的滥用倾向性，以及正向的药代动力学曲线。
噻奈普汀是最少参与到药物相互作用的，因为它并不会被肝脏中的细胞色素P450系统所代谢。在海马体和杏仁核中，噻奈普汀可参与到谷氨酸能传递过程并引起神经可塑性。
Preparation Note
噻奈普汀钠盐水合物可溶于 DMSO，浓度大于或等于 20 mg/ml。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
W Sohn et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(9), 860-e398-860-e398 (2012-06-12)
Tricyclic antidepressants have good efficacy in irritable bowel syndrome with diarrhea (IBS-D), but their clinical use is limited by considerations of tolerability. Tianeptine, another antidepressant, acts as a selective serotonin reuptake enhancer. We compared tianeptine with amitriptyline for the treatment
A Sah et al.
Translational psychiatry, 2, e171-e171 (2012-10-11)
Adult neurogenesis has been implicated in affective disorders and the action of antidepressants (ADs) although the functional significance of this association is still unclear. The use of animal models closely mimicking human comorbid affective and anxiety disorders seen in the
M Frankfurt et al.
Brain research, 696(1-2), 1-6 (1995-10-23)
Tianeptine is an atypical tricyclic antidepressant that facilitates serotonin (5-HT) reuptake. Tianeptine (10 mg/kg) or saline was administered intraperitoneally to male rats daily for 4 days. Monoamine levels were measured in micropunches of discrete brain nuclei that are implicated in
M Teresa Donato et al.
Journal of biomolecular screening, 17(3), 394-400 (2011-11-26)
In the present study, we developed a cell-based protocol for the identification of drugs able to induce steatosis. The assay measures multiple markers of toxicity in a 96-well plate format using high-content screening (HCS) technology. After treating HepG2 cells with
Oguz Mutlu et al.
Life sciences, 91(25-26), 1252-1262 (2012-10-17)
Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of
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