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T1783

Tobramycin sulfate salt 硫酸盐

Name: Tobramycin sulfate salt 硫酸盐
Brand: SIGMA

aminoglycoside antibiotic

别名:

Nebramycin Factor 6 sulfate

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关于此项目

经验公式（希尔记法）:

C₁₈H₃₇N₅O₉ · xH₂SO₄

分子量:

467.51 (free base basis)

NACRES:

NA.85

PubChem Substance ID:

329826686

UNSPSC Code:

51281677

MDL number:

MFCD00133864

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属性

biological source

Streptomyces tenebrarius

Quality Segment

200

form

powder

potency

634-739 μg per mg

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)

color

white to off-white

solubility

H₂O: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O

InChI

1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1

InChI key

ZEUUPKVZFKBXPW-TWDWGCDDSA-N

说明

General description

Chemical structure: aminoglycoside

Application

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance.

Biochem/physiol Actions

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA.

Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Packaging

100MG,500MG

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Disclaimer

吸湿

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H312 + H332,H360

pcodes

P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c