T2020
(±)-α-生育酚磷酸酯 二钠盐
water-soluble α-tocopherol analog
别名:
Alpha Tocopherol phosphate disodium salt
登录 查看组织和合同定价。
选择尺寸
关于此项目
线性分子式:
C29H49O5PNa2
化学文摘社编号:
分子量:
554.65
UNSPSC Code:
12352205
eCl@ss:
34058016
PubChem Substance ID:
NACRES:
NA.79
MDL number:
SMILES string
[Na].CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OP(O)(O)=O)c(C)c(C)c2O1
InChI
1S/C29H51O5P.Na.H/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(34-35(30,31)32)23(5)24(6)28(26)33-29;;/h20-22H,9-19H2,1-8H3,(H2,30,31,32);;
InChI key
QRLCTLIPEFQSSG-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥97% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white to off-white
storage temp.
2-8°C
Quality Level
Application
(±)-α-生育酚磷酸酯二钠盐已被用作抗氧化剂，用于评估其对大鼠海马神经元氧化损伤的保护作用。它还被用于研究其分子机制和跨质膜运输。
Biochem/physiol Actions
生育酚（TCP）（维生素E）是一系列（α、β、γ 和δ）手性有机分子，其色原烷醇环苯酚部分的甲基化程度不同。 生育酚是脂溶性抗氧化剂，可保护细胞膜免受氧化损伤。α-生育酚是人类优先吸收的生育酚形式。α-生育酚磷酸酯 (TocP)是与α生育酚乙酸酯、α-生育酚烟酸酯、α-生育酚琥珀酸酯和其他酯化形式一起，作为相似但活性不同的维生素E增补剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Adriana Sampayo-Reyes et al.
Acta biochimica Polonica, 53(3), 547-552 (2006-10-05)
Human glutathione S-transferase omega 1-1 (hGSTO1-1) is a newly identified member of the glutathione S-transferase (GST) family of genes, which also contains alpha, mu, pi, sigma, theta, and zeta members. hGSTO1-1 catalyzes the reduction of arsenate, monomethylarsenate (MMA(V)), and dimethylarsenate
R Libinaki et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 44(7), 916-932 (2005-12-13)
The safety of a formulation of mixed tocopheryl phosphates, (MTP) was evaluated in a series of toxicological tests in vivo using rats, mice and rabbits and in vitro using bacterial and mammalian cell cultures. The tests conducted included an oral
Yesim Negis et al.
IUBMB life, 57(1), 23-25 (2005-07-23)
The finding that alpha-tocopheryl phosphate is present in cells in small amounts, that it can be synthesized and hydrolyzed supports the hypothesis that alpha-tocopheryl phosphate might be a signaling molecule. The possible pathways needed for the synthesis, hydrolysis and signaling
Jean-Marc Zingg et al.
Free radical biology & medicine, 49(12), 1989-2000 (2010-10-07)
The natural vitamin E analog α-tocopheryl phosphate (αTP) modulates atherosclerotic and inflammatory events more efficiently than the unphosphorylated α-tocopherol (αT). To investigate the molecular mechanisms involved, we have measured plasma levels of αTP and compared the cellular effects of αT
Yesim Negis et al.
Nutrition and cancer, 61(6), 875-878 (2010-02-16)
Protection by vitamin E against free radical-induced DNA mutations appears not to be an effective occurrence. On the other hand, in vitro evidence that different tocopherols slow down cell proliferation is an accepted observation. However, such an event may not
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持