T2020
(±)-α-生育酚磷酸酯 二钠盐
water-soluble α-tocopherol analog
别名:
Alpha Tocopherol phosphate disodium salt
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关于此项目
线性分子式:
C29H49O5PNa2
化学文摘社编号:
分子量:
554.65
MDL编号:
UNSPSC代码:
12352205
eCl@ss:
34058016
PubChem化学物质编号:
NACRES:
NA.79
生物来源
synthetic (organic)
质量水平
方案
≥97% (HPLC)
表单
powder
技术
HPLC: suitable
颜色
white to off-white
储存温度
2-8°C
SMILES字符串
[Na].CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OP(O)(O)=O)c(C)c(C)c2O1
InChI
1S/C29H51O5P.Na.H/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(34-35(30,31)32)23(5)24(6)28(26)33-29;;/h20-22H,9-19H2,1-8H3,(H2,30,31,32);;
InChI key
QRLCTLIPEFQSSG-UHFFFAOYSA-N
应用
(±)-α-生育酚磷酸酯二钠盐已被用作抗氧化剂，用于评估其对大鼠海马神经元氧化损伤的保护作用。它还被用于研究其分子机制和跨质膜运输。
生化/生理作用
生育酚（TCP）（维生素E）是一系列（α、β、γ 和δ）手性有机分子，其色原烷醇环苯酚部分的甲基化程度不同。 生育酚是脂溶性抗氧化剂，可保护细胞膜免受氧化损伤。α-生育酚是人类优先吸收的生育酚形式。α-生育酚磷酸酯 (TocP)是与α生育酚乙酸酯、α-生育酚烟酸酯、α-生育酚琥珀酸酯和其他酯化形式一起，作为相似但活性不同的维生素E增补剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jean-Marc Zingg et al.
BioFactors (Oxford, England), 38(1), 24-33 (2012-01-28)
Vitamin E was originally discovered as a dietary factor essential for reproduction in rats. Since then, vitamin E has revealed many important molecular properties such as the scavenging of reactive oxygen and nitrogen species or the modulation of signal transduction
Jean-Marc Zingg et al.
Molecular nutrition & food research, 54(5), 679-692 (2010-02-20)
The vitamin E (alpha-tocopherol, alphaT) derivative, alpha-tocopheryl phosphate (alphaTP), is detectable in small amounts in plasma, tissues, and cultured cells. Studies done in vitro and in vivo suggest that alphaT can become phosphorylated and alphaTP dephosphorylated, suggesting the existence of
Satomi Nakayama et al.
The Journal of investigative dermatology, 121(2), 406-411 (2003-07-26)
The ability of the novel water-soluble provitamin E, alpha-tocopherol-6-O-phosphate, to protect against ultraviolet B-induced damage in cultured mouse skin was investigated and compared with the protectiveness of alpha-tocopherol acetate in cultured mouse skin. Pretreatment of skin with 0.5% (9.4 mM)
Molecular mechanism of alpha-tocopheryl-phosphate transport across the cell membrane
Negis Y, et al.
Biophysical Chemistry (2007)
Adriana Sampayo-Reyes et al.
Acta biochimica Polonica, 53(3), 547-552 (2006-10-05)
Human glutathione S-transferase omega 1-1 (hGSTO1-1) is a newly identified member of the glutathione S-transferase (GST) family of genes, which also contains alpha, mu, pi, sigma, theta, and zeta members. hGSTO1-1 catalyzes the reduction of arsenate, monomethylarsenate (MMA(V)), and dimethylarsenate
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