T2252
脱铁转铁蛋白 人
≥95% protein basis (biuret)
别名:
人转铁蛋白, 铁传递蛋白
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
eCl@ss:
34058011
Form:
powder
Assay:
≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis)
Biological source:
human
Mol wt:
76-81 kDa
biological source
human
Quality Level
assay
≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis)
form
powder
mol wt
76-81 kDa
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 50 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TF(7018)
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General description
转铁蛋白是一种双叶糖蛋白，含有一个N端叶和一个N端叶。每个结构域被分为两个子结构域，在子结构域之间的间隙中是金属结合位点。一个转铁蛋白分子可以与两个铁离子结合。脱铁转铁蛋白呈现无铁形式。
Application
人脱铁转铁蛋白已用于杜氏改良Eagle培养基/营养混合物以培养：
- 胰导管腺癌（PDAC）细胞系
- 少突胶质细胞
- 肾近端小管上皮细胞（RPTEC/TERT1）
转铁蛋白可以强烈抑制细菌与生物材料的粘附，包括聚苯乙烯、聚甲基丙烯酸甲酯和硅氧烷。在培养基中，20 ug/ml 可以观察到抑制作用 。
Biochem/physiol Actions
转铁蛋白通过受体介导的内吞作用运输铁。铁转运机制发生在血脑屏障的内皮细胞中。转铁蛋白维持铁稳态，是一种铁相关标记物。重症COVID-19中观察到转铁蛋白水平下降。它可以与铁以外的其他分子结合，因此可以用于靶向药物输送。
Other Notes
非血红素铁转运蛋白。
Disclaimer
供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
高风险级别生物产品--人源产品
此项目有
Catherine Claise et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 116, 74-79 (2021-12-25)
Mounting evidence links hyperinflammation in gravely ill patients to low serum iron levels and hyperferritinemia. However, little attention has been paid to other iron-associated markers such as transferrin. The aim of this study was to investigate the association of different
Reza Ardehali et al.
Artificial organs, 26(6), 512-520 (2002-06-20)
Apo-transferrin (apo-Tf), the iron deficient form of Tf, has been identified previously as a potent inhibitor of Staphylococcus epidermidis adhesion to polyurethane surfaces. In this study, the ability of apo-Tf to suppress the adhesion of two other strains of bacteria
Camila Campos-Escamilla et al.
International journal of molecular sciences, 22(24) (2021-12-25)
Human serum transferrin (Tf) is a bilobed glycoprotein whose function is to transport iron through receptor-mediated endocytosis. The mechanism for iron release is pH-dependent and involves conformational changes in the protein, thus making it an attractive system for possible biomedical
Agostina Nardone et al.
Cell and tissue banking, 10(4), 301-308 (2009-02-03)
In breast cancer, various clinical parameters are assessed to define clinical stage and thus obtain a more accurate prognosis. However, banks of tumor tissues are an important source of material for studies of risk of recurrence and of features governing
Jacob M Smigiel et al.
Molecular cancer research : MCR, 15(4), 478-488 (2017-01-06)
Pancreatic ductal adenocarcinoma (PDAC) is referred to as a silent killer due to the lack of clear symptoms, a lack of early detection methods, and a high frequency of metastasis at diagnosis. In addition, pancreatic cancer is remarkably resistant to
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Instructions
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T2252-100MG | 04061837341885 |
| T2252-500MG | 04061837341908 |
| T2252-5G | 04061837341922 |
| T2252-1G | 04061837341892 |
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