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Merck
CN

T2252

脱铁转铁蛋白 人

≥95% protein basis (biuret)

别名:

人转铁蛋白, 铁传递蛋白

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关于此项目

化学文摘社编号:
11096-37-0
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
MFCD00130536

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产品名称

脱铁转铁蛋白 人, ≥95% protein basis (biuret)

biological source

human

assay

≥95% protein basis (biuret)
≥98% (agarose gel electrophoresis)

form

powder

mol wt

76-81 kDa

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

UniProt accession no.

P02787

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... TF(7018)

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Disclaimer

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

General description

转铁蛋白是一种双叶糖蛋白，含有一个N端叶和一个N端叶。每个结构域被分为两个子结构域，在子结构域之间的间隙中是金属结合位点。一个转铁蛋白分子可以与两个铁离子结合。脱铁转铁蛋白呈现无铁形式。

Other Notes

非血红素铁转运蛋白。

Application

人脱铁转铁蛋白已用于杜氏改良Eagle培养基/营养混合物以培养：
  • 胰导管腺癌（PDAC）细胞系
  • 少突胶质细胞
  • 肾近端小管上皮细胞（RPTEC/TERT1）

转铁蛋白可以强烈抑制细菌与生物材料的粘附，包括聚苯乙烯、聚甲基丙烯酸甲酯和硅氧烷。在培养基中，20 ug/ml 可以观察到抑制作用 。

Biochem/physiol Actions

转铁蛋白通过受体介导的内吞作用运输铁。铁转运机制发生在血脑屏障的内皮细胞中。转铁蛋白维持铁稳态，是一种铁相关标记物。重症COVID-19中观察到转铁蛋白水平下降。它可以与铁以外的其他分子结合，因此可以用于靶向药物输送。

存储类别

11 - Combustible Solids

wgk

WGK 3

法规信息

高风险级别生物产品--人源产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000504263
0000504263
0000504337
0000504337
0000489134

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the carbohydrate content of human transferrin?

    We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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