T2824
Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster
~2 mg/mL, clone TN3-19.12, purified immunoglobulin, buffered aqueous solution
别名:
Anti-TNF-α
产品名称
Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster, ~2 mg/mL, clone TN3-19.12, purified immunoglobulin, buffered aqueous solution
biological source
hamster
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TN3-19.12, monoclonal
form
buffered aqueous solution
species reactivity
rat, mouse
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
neutralization: suitable
western blot: 0.25-0.5 μg/mL using recombinant mouse TNF-α
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Tnf(21926)
rat ... Tnf(24835)
Application
Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster has been used in:
- immunoblotting
- enzyme-linked immunosorbent assay (ELISA)
- immunoprecipitation
- neutralization
Biochem/physiol Actions
Mouse monoclonal clone TN3-19.12 anti-Tumor Necrosis Factor-α antibody recognizes mouse and rat TNF-α (approx. 17 kDa in its monomer form and 51 kDa in its homotrimer form) and cross-reacts with mouse TNF-β.
TNF-α is a major mediator of inflammatory responses and its over-production results in extensive tissue damage associated with endotoxemia and cachexia. High serum levels of TNF are associated with septic shock, rejection of renal transplants, parasitic infections, and various neoplastic diseases. TNF-α exhibits growth-enhancing activities for normal cells like fibroblasts, T and B cells, activation of endothelial cells, and differentiation of myeloid cells. In neoplastic cells, TNF-α exerts growth inhibitory activities that can be either cytostatic or cytotoxic.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Mouse Tumor Necrosis Factor-α (TNF-α) is derived from the TN3-19.12 hybridoma produced by the fusion of mouse myeloma cells (P3X63-Ag8.653) and splenocytes from male Armenian hamster immunized with purified mouse recombinant TNF-α. Tumor necrosis factor (TNF) protein family contains two members: TNF-α (also known as cachectin) and TNF-β (also known as lymphotoxin). These proteins are small molecules with a molecular weight of 17 and 25 kDa respectively and share 30% amino acid homology. TNF-α and -β are secreted from many different cells such as lymphocytes, neutrophils, and macrophages.
Immunogen
purified recombinant mouse TNF-α.
Physical form
Supplied as a 0.2 μm filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Cytokines, inflammation and pain
Zhang JM and An J
International Anesthesiology Clinics, 45(2), 27-27 (2007)
Role of the Adipocyte in Metabolism and Endocrine Function
Endocrinology: Adult and Pediatric (2016)
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