T2825
TIQ-A
≥98% (HPLC), solid
别名:
Thieno[2,3-c]isoquinolin-5-one
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关于此项目
经验公式（希尔记法）:
C11H7NOS
化学文摘社编号:
分子量:
201.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 16 mg/mL
storage temp.
2-8°C
SMILES string
O=C1Nc2sccc2-c3ccccc13
InChI
1S/C11H7NOS/c13-10-8-4-2-1-3-7(8)9-5-6-14-11(9)12-10/h1-6H,(H,12,13)
InChI key
LQJVOLSLAFIXSV-UHFFFAOYSA-N
Application
TIQ-A has been used as a PAPR-1 inhibitor to study eosinophilic infiltration into the airways of OVA-challenged mice1. It has also been used to study its role in the regression of atherosclerotic plaques in high-fat diet-fed ApoE(-/-) mice2.
Biochem/physiol Actions
TIQ-A is a potent inhibitor of PARP, anti-apoptotic.
Preparation Note
TIQ-A is soluble in DMSO at 16 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves