Tissue plasminogen activator chromogenic substrate is a highly sensitive chromogenic peptide substrate for tissue plasminogen activator (tPA). It shows different sensitivity to native single-chain tPA (sc-tPA) and its fully active two-chain form (tc-tPA).

Tissue plasminogen activator chromogenic substrate has been used:

• in tissue plasminogen activator inhibition assay
• to determine the plasminogen activator (PA) activity by studying the glycosylation properties of tissue plasminogen activator (tPA) activities in effusions using concanavalin A-Sepharose (conA-S) chromatography
• in inhibition assays and complex formation analyses of wild type (WT) neuroserpin (NS) and its variants