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T3077

TRO 19622

Name: TRO 19622
Brand: SIGMA

≥98% (HPLC), solid

别名:

NSC 21311, cholest-4-en-3-one, oxime

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关于此项目

经验公式（希尔记法）:

C₂₇H₄₅NO

化学文摘社编号:

22033-87-0

分子量:

399.65

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

InChI

1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+

InChI key

QNTASHOAVRSLMD-SGWCAAJKSA-N

说明

Application

TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons². TRO 19622 is also known to stimulate myelin repair in rat models of demyelination³.

Biochem/physiol Actions

TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain⁴.

Preparation Note

TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
T3077-25MG	04061832983912
T3077-5MG	04061832983929