跳转至内容
Merck
CN

T3125

四氢叶酸

≥65% (when packaged), powder

别名:

5,6,7,8-四氢蝶酰基-L-谷氨酸, THF

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C19H23N7O6
化学文摘社编号:
135-16-0
分子量:
445.43
UNSPSC Code:
12352204
NACRES:
NA.51
PubChem Substance ID:
24900106
EC Number:
205-181-1
Beilstein/REAXYS Number:
9238187
MDL number:
MFCD00135583
Form:
powder
Solubility:
0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow
Biological source:
synthetic
Color:
faintly yellow to light brown

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

InChI

1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChI key

MSTNYGQPCMXVAQ-KIYNQFGBSA-N

SMILES string

NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1

biological source

synthetic

form

powder

concentration

≥65% (when packaged)

color

faintly yellow to light brown

solubility

0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow

storage temp.

−20°C

Quality Level

200

Application

四氢叶酸也可用作标准品，生成标准曲线用于通过高效液相色谱法(HPLC)定量分析牛奶培养物中嗜热链球菌产生的叶酸类型。它还适用于来自扭脱甲基杆菌(M. extorquens)的叶酸-四氢叶酸连接酶(MeFtfL)的酶活检测。
四氢叶酸已用于测定四氢叶酸对多形核髓源性抑制细胞(PMN-MDSC)的抑制作用。四氢叶酸(THF)最近被用于研究核糖开关的活性。

Biochem/physiol Actions

四氢叶酸是为氨基酸、核酸和脂质提供一碳单位的叶酸盐衍生物的母体分子。四氢叶酸盐代谢物参与嘌呤和嘧啶的合成以及氨基酸的合成和转化

Packaging

密封安瓿瓶。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000496153
0000496153
0000483083
0000483083
0000426528

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Yoko Chiba et al.
The FEBS journal, 279(3), 504-514 (2011-12-07)
Serine hydroxymethyltransferase catalyzes the cleavage of β-hydroxyamino acids into glycine and aldehydes in the absence of tetrahydrofolate. The enzyme accepts various β-hydroxyamino acids as the substrate of this reaction. The reaction rate varies depending on the substituent and stereochemistry at
Tyler D Ames et al.
Chemistry & biology, 17(7), 681-685 (2010-07-28)
Comparative sequence analyses of bacterial genomes are revealing many structured RNA motifs that function as metabolite-binding riboswitches. We have identified an RNA motif frequently positioned in the 5' UTRs of folate transport and biosynthesis genes in Firmicute genomes. Biochemical experiments
Avinash C Srivastava et al.
Plant physiology, 155(3), 1237-1251 (2011-01-15)
A recessive Arabidopsis (Arabidopsis thaliana) mutant with short primary roots and root hairs was identified from a forward genetic screen. The disrupted gene in the mutant encoded the plastidial isoform of folylpolyglutamate synthetase (FPGS), previously designated as AtDFB, an enzyme
Francisco García-Molina et al.
Journal of agricultural and food chemistry, 59(4), 1383-1391 (2011-01-27)
The coenzyme tetrahydrofolic acid is the most rapid suicide substrate of tyrosinase that has been characterized to date. A kinetic study of the suicide inactivation process provides the kinetic constants that characterize it: λ(max), the maximum apparent inactivation constant; r
Aurora Meucci et al.
Food microbiology, 69, 116-122 (2017-09-25)
The ability of folate-producer strains of Streptococcus thermophilus to accumulate folates and the expression of two target genes (folK and folP), involved in the folate biosynthesis, were studied during milk fermentation. An over-expression of folK took place only in the
查看所有相关文献

商品

Folic Acid Metabolism in Cancer

Cancer research innovations address the complexity of the disease, providing advanced technologies for varied applications.

Folic Acid Metabolism in Cancer

Biofiles reviews innovative technologies for cancer research, reflecting the complexity of the disease.

癌症中的叶酸代谢

本期生物档案回顾了我们的一些最新和最具创新性的技术及其在癌症研究中的具体应用。在准备本期生物档案时，有人指出癌症极为复杂，要确定一个与其他主题完全无关的主题极为困难。。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持