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Merck
CN

T3125

Sigma-Aldrich

四氢叶酸

≥65% (when packaged), powder

别名:

5,6,7,8-四氢蝶酰基-L-谷氨酸, THF

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关于此项目

经验公式（希尔记法）:
C19H23N7O6
CAS Number:
135-16-0
分子量:
445.43
Beilstein:
9238187
EC 号:
205-181-1
MDL编号:
MFCD00135583
UNSPSC代码:
12352204
PubChem化学物质编号:
24900106
NACRES:
NA.51

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生物来源

synthetic

质量水平

200

表单

powder

浓度

≥65% (when packaged)

颜色

faintly yellow to light brown

溶解性

0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow

储存温度

−20°C

SMILES字符串

NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1

InChI

1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChI key

MSTNYGQPCMXVAQ-KIYNQFGBSA-N

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相关类别

应用

四氢叶酸也可用作标准品，生成标准曲线用于通过高效液相色谱法(HPLC)定量分析牛奶培养物中嗜热链球菌产生的叶酸类型。它还适用于来自扭脱甲基杆菌(M. extorquens)的叶酸-四氢叶酸连接酶(MeFtfL)的酶活检测。
四氢叶酸已用于测定四氢叶酸对多形核髓源性抑制细胞(PMN-MDSC)的抑制作用。四氢叶酸(THF)最近被用于研究核糖开关的活性。

生化/生理作用

四氢叶酸是为氨基酸、核酸和脂质提供一碳单位的叶酸盐衍生物的母体分子。四氢叶酸盐代谢物参与嘌呤和嘧啶的合成以及氨基酸的合成和转化

包装

密封安瓿瓶。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000483083
0000483083
0000426528
0000414036
0000414036

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