T3146
三甲丙咪嗪标准液 马来酸盐
≥98% (TLC), serotonin transport blocker, powder
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经验公式（希尔记法）:
C20H26N2 · C4H4O4
化学文摘社编号:
分子量:
410.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
208-318-3
MDL number:
产品名称
三甲丙咪嗪标准液 马来酸盐, ≥98% (TLC), powder
InChI key
YDGHCKHAXOUQOS-WLHGVMLRSA-N
InChI
1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES string
OC(=O)\C=C\C(O)=O.CC(CN(C)C)CN1c2ccccc2CCc3ccccc13
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow
originator
Sanofi Aventis
storage temp.
2-8°C
Quality Level
Gene Information
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Application
Trimipramine maleate has been used to develop chiral separation methods using capillary electrophoresis4.
Biochem/physiol Actions
Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake.
Preparation Note
Trimipramine maleate is soluble in chloroform at 50 mg/ml to yield a clear, colorless to faint yellow solution.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
G Chouinard et al.
Cellular and molecular neurobiology, 19(4), 533-552 (1999-06-24)
1. The benzodiazepines are among the most frequently prescribed of all drugs and have been used for their anxiolytic, anticonvulsant, and sedative/hypnotic properties. Since absorption rates, volumes of distribution, and elimination rates differ greatly among the benzodiazepine derivatives, each benzodiazepine
F Plenge-Tellechea et al.
Archives of biochemistry and biophysics, 370(1), 119-125 (1999-09-25)
Tricyclic antidepressants are moderately potent inhibitors of the plasma membrane Ca(2+)-ATPase activity measured in erythrocyte ghosts. For the calmodulin-activated activity, half-maximal inhibition was observed in the presence of 0.25 mM clomipramine. Desipramine, imipramine, and trimipramine show half-maximal inhibition in the
Chiral separation in non-aqueous media by capillary electrophoresis using the ion-pair principle.
Bjornsdottir, I., et al.
Journal of Chromatography A, 745(1), 37-44 (1996)
J M Langosch et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(3), 209-212 (1998-08-26)
Trimipramine has been classified as an atypical tricyclic antidepressant, because only weak inhibitory effects on serotonin and/or noradrenaline reuptake have been found. Since some antidepressive drugs (e.g. imipramine) and other agents used in the treatment of affective disorders (e.g. carbamazepine)
Emin Aghayev et al.
Journal of forensic and legal medicine, 17(3), 164-168 (2010-03-10)
In clinical medicine, plane radiography is used for detecting the remains of medications in the stomach in oral medication intoxication cases. Since postmortem computed tomography (CT), performed prior to autopsy, is currently intensively entering the forensic routine, the technique was
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