T3202
Torsemide
≥98% (HPLC), solid
别名:
Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
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关于此项目
经验公式（希尔记法）:
C16H20N4O3S
化学文摘社编号:
分子量:
348.42
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
溶解性
DMSO: soluble 18 mg/mL
H2O: insoluble
创始人
Roche
SMILES字符串
CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
InChI
1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChI key
NGBFQHCMQULJNZ-UHFFFAOYSA-N
基因信息
human ... SLC12A1(6557)
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相关类别
应用
Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.
生化/生理作用
Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.
特点和优势
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
制备说明
Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
H A Friedel et al.
Drugs, 41(1), 81-103 (1991-01-01)
Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from
Livia Saleh et al.
Plant signaling & behavior, 8(6), e24259-e24259 (2013-04-23)
The involvement of chloride in salt stress symptoms and salt tolerance mechanisms in plants has been less investigated in the past. Therefore, we studied the salt-induced chloride influx in Arabidopsis expressing the GFP-based anion indicator Clomeleon. High salt concentrations induce
Clinical therapeutics, 33(9), 1204-1213 (2011-09-13)
The pharmacologic modification of the synthesis and deposition of fibrillar collagen in the myocardium may have effects on the cardiac function, clinical status, and prognosis of patients with heart failure (HF). Serum procollagen type I carboxyterminal peptide (PICP) is a
[Treatment of nephritic edema by torasemide in children].
Qi Li et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 13(6), 520-521 (2011-06-16)
Cuixia Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 1084-1090 (2011-06-11)
In pH 0.6-1.1 HCl-NaAc buffer solution, torasemide (TOR) reacted with TP to form a 3:1 ion-association complexes. As a result, not only the absorption spectra were changed, but also the intensities of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and
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