T3202
Torsemide
≥98% (HPLC), solid
别名:
Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
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关于此项目
经验公式（希尔记法）:
C16H20N4O3S
化学文摘社编号:
分子量:
348.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 18 mg/mL, H2O: insoluble
originator
Roche
SMILES string
CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
InChI
1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChI key
NGBFQHCMQULJNZ-UHFFFAOYSA-N
Gene Information
human ... SLC12A1(6557)
Application
Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.
Biochem/physiol Actions
Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves