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安全信息

T3202

Sigma-Aldrich

Torsemide

≥98% (HPLC), solid

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别名:
Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
经验公式（希尔记法）:
C16H20N4O3S
CAS号:
56211-40-6
分子量:
348.42
MDL编号:
MFCD00866166
PubChem化学物质编号:
329826741
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

solid

溶解性

DMSO: soluble 18 mg/mL
H2O: insoluble

创始人

Roche

SMILES string

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChI key

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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应用

Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.

生化/生理作用

Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

制备说明

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险声明

H319 - H361fd

危险分类

Eye Irrit. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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H A Friedel et al.
Drugs, 41(1), 81-103 (1991-01-01)
Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from
Livia Saleh et al.
Plant signaling & behavior, 8(6), e24259-e24259 (2013-04-23)
The involvement of chloride in salt stress symptoms and salt tolerance mechanisms in plants has been less investigated in the past. Therefore, we studied the salt-induced chloride influx in Arabidopsis expressing the GFP-based anion indicator Clomeleon. High salt concentrations induce
Clinical therapeutics, 33(9), 1204-1213 (2011-09-13)
The pharmacologic modification of the synthesis and deposition of fibrillar collagen in the myocardium may have effects on the cardiac function, clinical status, and prognosis of patients with heart failure (HF). Serum procollagen type I carboxyterminal peptide (PICP) is a
Cuixia Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 1084-1090 (2011-06-11)
In pH 0.6-1.1 HCl-NaAc buffer solution, torasemide (TOR) reacted with TP to form a 3:1 ion-association complexes. As a result, not only the absorption spectra were changed, but also the intensities of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and
[Etiologies of nephrotic syndrome].
S Heeringa et al.
Praxis, 100(9), 505-514 (2011-04-29)
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